Type of prosthesis
Twenty-tree studies reported using solely a biological valve-containing prosthesis (14-36): 13 studies with Freestyle bioprostheses, 3 Shelhigh bioconduit, 2 studies Bio-Valsalva prosthesis, 1 Edwards S prima Plus, 2 with mixed stentless prosthesis. In one study the type of the biological valve was unspecified (37). Two studies included both stentless and stented bioprostheses (38, 39). Five studies used (almost) exclusively self-made aortic root prosthesis using a stented bioprostheses (bio-Bentall) to replace the aortic root. (40-44).
No associations were found between late mortality or reintervention, and the type of prosthesis used. Table 3 shows detailed information on valve-related outcome for “stentless” and “stented” subgroups.Duration of follow-up
A subgroup analysis was performed with 12 studies with a mean follow-up of at least 5 years ̵̶ pooled weighted mean of 7.4 years (range 5.0 to 10.1 years) ̵̶ with a pooled mean age of 65.9 years, and compared to the other 19 studies, with a mean follow-up of 2.56 years (1.0 to 4.8 years) and pooled mean age of 65.8 were analyzed. Table 4 shows details on outcome.
Microsimulation predictions of age-specific life expectancy and outcomeMicrosimulation-based estimates of life expectancy and lifetime risk of valve-related morbidity for 60, 65 and 70 years old patients are shown in Figure 2. The microsimulation model calibration with the pooled mortality is shown is Supplementary file 4.