Parameters |
ACE2† |
TMPRSS2† |
FURIN† |
ACE2† |
TMPRSS2† |
FURIN† |
ACE2† |
TMPRSS2† |
FURIN† |
Age (years) |
0.009 (-0.005 to 0.024) |
-0.012 (-0.025 to 0.002) |
0.009
(-0.005 to 0.023) |
-0.006 (-0.018 to 0.007) |
-0.0005 (-0.014 to 0.013) |
0.002 (-0.012 to 0.016) |
0.003 (-0.012 to 0.019) |
0.012 (-0.005 to
0.028) |
0.088 (-0.012 to 0.016) |
Male (vs. female) |
0.320 (-0.078 to 0.718) |
0.194 (-0.186 to 0.575) |
-0.263 (-0.637 to 0.112) |
-0.183 (-0.537 to 0.170) |
0.350 (-0.018 to
0.719) |
0.533 (0.143 to 0.924)** |
0.086 (-0.328 to 0.500) |
0.281 (-0.156 to 0.718) |
0.183 (-0.258 to 0.624) |
Ever smoking (vs. never) |
-0.077 (-0.485 to 0.332) |
0.233 (-0.153 to
0.618) |
0.104 (-0.279 to 0.487) |
0.252 (-0.129 to 0.632) |
0.191
(-0.212 to 0.594) |
0.225 (-0.210 to 0.659) |
0.482 (0.031 to
0.933)* |
0.218 (-0.274 to 0.710) |
0.225 (-0.210 to
0.659) |
BMI (kg/m2) |
0.009 (-0.029 to 0.048) |
0.024 (-0.012
to 0.060) |
0.013 (-0.023 to 0.049) |
0.013 (-0.016 to 0.043) |
0.034 (0.003 to 0.064)* |
-0.014 (-0.048 to 0.019) |
-0.035
(-0.070 to 0.00001) |
0.004 (-0.035 to 0.042) |
-0.014 (-0.048 to
0.019) |
Sputum eosinophils (%)† |
0.0001 (-0.056 to 0.056) |
0.031 (-0.065 to
0.126) |
-0.080 (-0.152 to -0.008)*
|
-0.080 (-0.202 to 0.041),
n=24 |
-0.102 (-0.236 to 0.033), n=24 |
0.033 (-0.153 to 0.219), n=24 |
-0.053 (-0.235 to 0.130), n=27 |
-0.009 (-0.216 to 0.197), n=27 |
-0.030
(-0.206 to 0.146), n=27 |
Sputum neutrophils (%)† |
0.103 (-0.061 to 0.267) |
0.001 (-0.263 to
0.264) |
0.613 (0.438 to 0.788)*** |
-0.248 (-0.674 to 0.179),
n=24 |
-0.029 (-0.467 to 0.408), n=24 |
0.159 (-0.388 to 0.706), n=24 |
0.096 (-0.592 to 0.784), n=27 |
-0.293 (-1.098 to 0.512), n=27 |
0.040
(-0.629 to 0.709), n=27 |
Blood eosinophils (%)† |
0.166 (0.041 to 0.291)* |
0.072
(-0.134 to 0.278) |
-0.009 (-0.176 to 0.157) |
-0.057 (-0.183 to 0.068) |
0.015 (-0.113 to 0.143) |
0.121 (-0.032 to 0.274) |
-0.018 (-0.159 to
0.124) |
0.010 (-0.172 to 0.192) |
-0.011 (-0.184 to
0.163) |
Blood neutrophils (%)† |
0.300 (0.071 to 0.529)* |
-0.307
(-0.678 to 0.063) |
0.389 (0.095 to 0.682)* |
0.176 (-0.027 to
0.380) |
0.090 (-0.120 to 0.300) |
0.266 (0.014 to 0.519)* |
0.179 (-0.059 to 0.418) |
0.398 (0.099 to 0.697)* |
0.140
(-0.160 to 0.440) |
FeNO (ppb) |
0.001 (-0.005 to 0.006) |
0.001 (-0.004 to 0.007) |
-0.003
(-0.008 to 0.002) |
0.004 (-0.002 to 0.010) |
0.004 (-0.002 to 0.011) |
0.0002 (-0.007 to 0.007) |
-0.001 (-0.008 to 0.007) |
-0.005 (-0.013 to
0.003) |
0.0002 (-0.007 to 0.007) |
Serum periostin (ng/ml) |
0.005 (-0.008 to 0.018) |
-0.004 (-0.016 to
0.009) |
0.004 (-0.008 to 0.018) |
-0.007 (-0.021 to 0.008) |
-0.007
(-0.223 to 0.009) |
0.009 (-0.007 to 0.025) |
0.003 (-0.015 to 0.022) |
-0.010 (-0.030 to 0.010) |
0.009 (-0.007 to 0.025) |
Atopy (vs. no) |
0.010 (-0.471 to 0.491) |
0.254 (-0.202 to 0.711) |
-0.312 (-0.761 to 0.137) |
0.276 (-0.146 to 0.699) |
0.061 (-0.390 to
0.512) |
-0.013 (-0.501 to 0.475) |
0.345 (-0.132 to 0.821) |
-0.383
(-0.890 to 0.123) |
-0.013 (-0.501 to 0.475) |
Post-BD FEV1 (% predicted) |
-0.011 (-0.019 to -0.003)** |
0.007 (-0.001 to 0.015) |
-0.011 (-0.019 to -0.004)** |
0.006
(-0.002 to 0.014) |
-0.002 (-0.010 to 0.007) |
-.009 (-0.018 to 0.0004) |
-0.006 (-0.016 to 0.005) |
-0.007 (-0.018 to 0.004) |
-0.009 (-0.018
to 0.0004) |
Allergic rhinitis (vs. no) |
-0.029 (-0.440 to 0.381) |
0.069 (-0.314 to
0.452) |
-0.239 (-0.603 to 0.126) |
-0.007 (-0.376 to 0.362) |
-0.245
(-0.628 to 0.137) |
-0.287 (-0.701 to 0.127) |
-0.040 (-0.464 to 0.385) |
-0.218 (-0.667 to 0.231) |
-0.287 (-0.701 to 0.127) |
Nasal polyps (vs. no) |
0.341 (-0.081 to 0.763) |
0.054 (-0.352 to
0.459) |
0.228 (-0.168 to 0.623) |
-0.293 (-0.694 to 0.108) |
0.041
(-0.363 to 0.446) |
0.022 (-0.432 to 0.475) |
0.505 (0.027 to
0.982)* |
0.341 (-0.167 to 0.849) |
0.022 (-0.432 to
0.475) |
OCS use (vs. no) |
0.650 (0.273 to 1.027)** |
0.008 (-0.370 to
0.387) |
0.351 (-0.017 to 0.718) |
-0.408 (-0.769 to -0.047)* |
0.014 (-0.377 to 0.404) |
0.044 (-0.377 to 0.465) |
-0.302 (-0.735 to
0.130) |
0.356 (-0.104 to 0.816) |
0.044 (-0.377 to
0.465) |
Severe asthma (vs. non-severe) |
0.882 (0.408 to 1.356)*** |
-0.008 (-0.487 to 0.472) |
0.665 (0.210 to 1.120)** |
-0.063
(-0.435 to 0.310) |
0.205 (-0.186 to 0.596) |
0.005 (-0.377 to 0.471) |
0.321 (-0.107 to 0.749) |
0.391 (-0.064 to 0.845) |
0.047 (-0.377 to
0.471) |