Expression of signatures by gene set variation analysis
Gene set variation analysis (GSVA) was used to calculate sample-wise
enrichment scores (ESs) (17) for six asthma-associated gene signatures.
These gene sets each relate to a specific aspect of airway inflammation
and asthma pathogenesis (Supplementary Table S2 ). The
correlations between ESs and expression of ACE2, TMPRSS2, and FURIN were
calculated using Spearman’s correlation.