parameter categories no systemic reaction systemic reaction OR (95% CI)a p-value OR (95% CI)b p-value
age 1240 (93.0) 93 (7.0) 0.98 (0.96–1.00) 0.09 0.99 (0.96–1.01) 0.20
antihypertensive treatment with β-blockers or ACEI no 920 (92.6) 74 (7.4) 1.00 0.25 1.00 0.61
yes 319 (94.4) 19 (5.6) 0.74 (0.43–1.22) 0.87 (0.49–1.52)
cardiovascular disease no 734 (92.1) 63 (7.9) 1.00 0.11 .. ..
yes 498 (94.3) 30 (5.7) 0.69 (0.43–1.08) ..
bee venom no 879 (95.8) 39 (4.3) 1.00 <0.001 1.00 <0.001
yes 360 (87.0) 54 (13.0) 3.39 (2.20–5.27) 3.35 (2.17–5.16)
tryptase* ≤ 11.4µg/L 1010 (93.2) 74 (6.8) 1.00 0.16 .. ..
> 11.4µg/L 107 (89.2) 13 (10.8) 1.54 (0.83–2.90) ..
verified mastocytosis* no 1,144 (93.1) 85 (6.9) 1.00 0.41 .. ..
yes 29 (87.9) 4 (12.1) 1.71 (0.57–5.14) ..
sIgE levels (bee venom) >0.35–3.5 kU/l 96 (85.0) 17 (15.0) 1.00 0.99 .. ..
>3.5–17.5 kU/l 97 (85.1) 17 (14.9) 0.97 (0.46–2.06) ..
>17.5 kU/l 45 (84.9) 8 (15.1) 0.92 (0.34–2.31) ..
sIgE levels (vespid venom) >0.35–3.5 kU/l 270 (94.1) 17 (5.9) 1.00 0.15 .. ..
>3.5–17.5 kU/l 281 (96.9) 9 (3.1) 0.52 (0.22–1.17) ..
>17.5 kU/l 148 (97.4) 4 (2.6) 0.42 (0.12–1.17) ..
Grading Ring-Messmer (initial sting reaction) 1&2 714 (93.3) 51 (6.7) 1.00 0.66 .. ..
3&4 526 (92.6) 42 (7.4) 1.10 (0.72–1.69) ..
Premedication with H1-antihistamine no 606 (94.3) 37 (5.8) 1.00 0.07 .. ..
yes 634 (91.9) 56 (8.1) 1.67 (0.96–3.18) ..
up-dosing protocol conventional 104 (95.4) 5 (4.6) 1.00 0.50 .. ..
rush, cluster, ultrarush 1128 (93.1) 84 (6.9) 1.40 (0.54–4.23) ..