Effects of phenanthridine derivatives on skin tissue of
HQ-treated C57bl/6 mice
After the pharmacodynamic evaluation, all experimental mice were
euthanized, and the skin of the test area was removed, stained with
haematoxylin eosin (HE), and observed under a microscope. The tyrosinase
in the blood of drug-treated mice recovered remarkably and the MDA
content decreased significantly in a dose-dependent manner (Fig 4b)
compared to that in mice from the NC group. The results indicated that
in comparison to the skin of the blank control, there were considerably
fewer melanin granules and a thicker (10–20 layers of reticular
structure) stratum corneum in the skin of the negative control. In
contrast, skin samples from drug-treated groups displayed significantly
different clinical features, with considerably more melanin granules and
thinner (3-10 layers of reticular structure) stratum corneum (Fig. 4b).
Similar to the aforementioned situation, the number of melanin granules
in the skin of the compound-treated groups was significantly increased,
even with a low treatment dose.