Acknowledgements
We express great respect to all experimental animals that contributed to this research. This research was funded by the National Natural Science Foundation of China (81773610, 81973212); the Youth Innovation Promotion Association of CAS (2018429); the Central Asian Drug Discovery and Development Center of Chinese Academy of Sciences (CAM201801).
Open research (DATA AVAILABILITY STATEMENT)
The data that support the findings of this study are available from the corresponding author upon
reasonable request. Some data may not be made available because of privacy or ethical
restrictions.
Declaration of transparency and scientific rigour
This Declaration acknowledges that this paper adheres to the principles for transparent reporting and
scientific rigour of preclinical research as stated in the BJP guidelines for Design and Analysis, and
Animal Experimentation, and as recommended by funding agencies, publishers and other
organisations engaged with supporting research.
Open research (DATA AVAILABILITY STATEMENT)
The data that support the findings of this study are available from the corresponding author upon
reasonable request. Some data may not be made available because of privacy or ethical
restrictions.
Declaration of transparency and scientific rigour
This Declaration acknowledges that this paper adheres to the principles for transparent reporting and
scientific rigour of preclinical research as stated in the BJP guidelines for Design and Analysis, and
Animal Experimentation, and as recommended by funding agencies, publishers and other
organisations engaged with supporting research.