Author contributions
J.Z., X.S., and Z.D.Z. conceived the project design and performed the research. J.Z., Q.Y.T., M.Y.G., L.J.Z. performed sampling and laboratory work. X.S., M.H. performed bioinformatics analysis. J.Z., X.S. wrote the manuscript with significant contributions from A.S. and H.L.Y. All authors read and approved the final manuscript.