Results
Sixty-four patients were enrolled the study. There were 27(42%) male
and 37 (58%) female patients. Mean preoperative hospitalization period
of all patients were 6.6±4.3 days. 26 (40.6%) patients did not have any
comorbidities whereas 14 (21.9%) of had one and 24 (37.5%) of had
multiple chronic diseases.
Although preoperative blood glucose levels were above 200 mg/dL for 9
(14.1%) of patients and serum creatinine levels were above 2 mg/dl for
7 (10.9%) of patients, Other laboratory results were within normal
limits.
Mean admission MMT scores were 26.42±1.95, 25.48±3.02 and 23.95±3.68
point for MMT1, MMT2 and MMT3, respectively. A statistically
significance was observed in consecutive total MMT score measurements
(p<0.001). We observed mean MMT1 total score was significantly
higher than mean MMT2 and MMT3 total scores whereas mean MMT2 total
score was higher than mean MMT3 total scores.
Mean MMT1 total score was calculated as 26.67±2.17 for Group 1 and
26.11±1.62 for Group 2. There was no statistical significance was found
according to mean MMT1 total scores between 2 groups (p=0.350). Table 1
summarizes the association between POCD and demographic values between
groups. There were statistically significance between POCD development
and age, education level, employment status whereas no difference was
found between POCD development and gender.
Table 2 summarized the differences between clinicopathological
characteristics, perioperative factors and groups. Statistical
significance was observed between groups in terms of preoperative
hospitalization period (p<0.001) and it was significantly
longer in POCD patients. According to our results, the presence of
comorbidity causes the development of POCD and prolonging preoperative
hospitalization period that attribute the development of POCD (p=0.025).
High ASA score, prolonged surgery time, preoperative low hematocrite
level (<30), ephedrine administration ve increased hemorrhage
during surgery were associated POCD development (table -2). Table-3
summarized the association between ASA scores and POCD development.
According to table-3, we statistically found significance between more
POCD development and increased ASA scores.
When comorbidities were separately analysed, a significant association
was observed between POCD development with hypertension and coronary
artery disease (p=0.036), (p=0.015). There were no statistical
significance between POCD development and diabetes mellitus (DM)
(p=0.353), chronic obstructive pulmoner disease (COPD)(p=0.353),
congestive heart failure (CHF) (p=0.259). Also, there were no
statistical significance between prolonged preoperative hospitalization
periods with hypertension, coronary artery diseases, DM, COPD and CHF,
respectively (p=0,2), (p=0,076), (p=0,153), (p=0,307), (p=0,324). And
also, there were no statistical significance between POCD development
with tobacco use, glucose and creatinine levels (p: 0,863), (p:0,488),
(p: 0,488).