1 PGx level of drug-gene pairs accodring to PharmGKB,genes in bold feature at least one corresponding drug with a
PGx level of required / recommended, informative not listed2 Variant Phenotype = ”non-normal” phenotype according
to PharmGKB, not all variants are clinically relevant3 PGx level has been changed to actionable by FDA for
rosuvastatin and to recommended by Swissmedic for simvastatin during the
course of the study4 Re-Check with SONOGEN how to phrase this
> 50 % prevalence of non-wildtype…