Statistical analysis
Statistical analyses were performed using a R software package
(http://www.r-project.org). The
chi-square test was used to compare differences in categorical variables
between each group. The RSI, RFS score, treatment periods, and various
parameters in the 24-h MII-pH monitoring between non-responders and
responders with LPR were compared using Student’s t -test. Ap -value <0.05 was considered to be statistically
significant. Significantly different parameters in the 24-h MII-pH
monitoring between two groups were analyzed using the receiver operating
characteristic (ROC) curve to determine the cut-off value to predict
responders with LPR.