Author contributions
E.N.F., M.L.T.M.P. and C.A.M.H. designed the research. E.N.F., V.K., D.R.C. and A.G.C., performed the experiments. T.B.O assisted in PCA and statistical analysis. E.N.F., M.L.T.M.P., C.A.M.H., R.M.P., W.D.S and J.N.S. assisted the experimental design, analyzed and discussed the data. E.N.F wrote the manuscript with contributions from all the coauthors. All authors approved the final version of the manuscript.