Timepoint 1 (lockdown- phase 1) |
Mean EASI score (±SD)
ç
|
Mean EASI score (±SD) ç
|
6.6
(7.8) #
|
8.2 (7.5) #
|
6.8
(7.7) |
|
Mean itch-NRS score (±SD) |
Mean itch-NRS score (±SD) |
2.4 (2.1) |
3.7 (2.3) |
2.6 (2.2) |
|
Mean sleep-NRS score (±SD) |
Mean sleep-NRS score (±SD) |
1.6 (2.0) |
2.7 (2.4) |
1.7 (2.1) |
|
AD-NRS score (±SD) |
AD-NRS score (±SD) |
2.3 (2.0) |
3.5 (2.2) |
2.5
(2.1) |
|
Self-reported AD status§
|
Improved n. pts (%) |
454 (28.8%) |
39 (15.5%) |
493 (27.0%) |
|
|
Stable n. pts (%) |
961 (60.9%) |
122 (48.6%) |
1083
(59.2%) |
|
|
Worsened n. pts (%) |
162 (10.3%) |
90 (35.9%) |
252
(13.8%) |
Timepoint 2
(phase 2)
|
Mean itch-NRS score (±SD)
|
Mean itch-NRS score (±SD)
|
2.4 (2.1)
|
3.7 (2.3)
|
2.6 (2.2)
|
|
Mean sleep-NRS score (±SD) |
Mean sleep-NRS score (±SD) |
1.5 (1.8) |
2.8 (2.8) |
1.6 (2.0) |
|
AD-NRS score (±SD) |
AD-NRS score (±SD) |
2.1 (1.9) |
3.7 (2.6) |
2.3
(2.1) |
|
Self-reported AD status§
|
Improved n. pts (%) |
417 (27.2%) |
53 (22.1%) |
470 (26.5%) |
|
|
Stable n. pts (%) |
980 (63.8%) |
102 (42.5%) |
1082
(61.0%) |
|
|
Worsened n. pts (%) |
138 (9.0%) |
85 (35.4%) |
223
(12.6%) |
Timepoint 3
(phase 3)
|
Mean EASI score (±SD)ç
|
Mean EASI score (±SD)ç
|
2.8 (3.4)
|
7.3 (7.7)
|
3.4 (4.4)
|
|
Mean itch-NRS score (±SD) |
Mean itch-NRS score (±SD) |
3.3 (2.6) |
3.3 (2.6) |
2.2 (2.1) |
|
Mean sleep-NRS score (±SD) |
Mean sleep-NRS score (±SD) |
1.2 (1.7) |
2.2 (2.4) |
1.3 (1.9) |
|
AD-NRS score (±SD) |
AD-NRS score (±SD) |
1.9 (1.9) |
3.0 (2.4) |
2.1
(2.0) |
|
Self-reported AD status§
|
Improved n. pts (%) |
442 (30.2%) |
69 (30.7%) |
511 (30.3%) |
|
|
Stable n. pts (%) |
921 (62.9%) |
113 (50.2%) |
1034
(61.2%) |
|
|
Worsened n. pts (%) |
101 (6.9%) |
43 (19.1%) |
144
(8.5%) |
Change in EASI score from timepoint 1 to timepoint 3 |
Change in EASI
score from timepoint 1 to timepoint 3 |
Change in EASI score from
timepoint 1 to timepoint 3 |
-2.8 (7.1) |
-0.2 (7.7) |
-2.5
(7.2)* |
Change in itch-NRS from timepoint 1 to timepoint 3 |
Change in itch-NRS
from timepoint 1 to timepoint 3 |
Change in itch-NRS from timepoint 1 to
timepoint 3 |
-0.3 (2.0) |
-0.2 (2.7) |
-0.3 (2.1)* |
Change in sleep-NRS from timepoint 1 to timepoint 3 |
Change in
sleep-NRS from timepoint 1 to timepoint 3 |
Change in sleep-NRS from
timepoint 1 to timepoint 3 |
-0.3 (1.9) |
-0.3 (2.8) |
-0.3
(2.0)* |
Change in AD-NRS from timepoint 1 to timepoint 3 |
Change in AD-NRS from
timepoint 1 to timepoint 3 |
Change in AD-NRS from timepoint 1 to
timepoint 3 |
-0.4 (1.8) |
-0.3 (2.4) |
-0.4 (1.9)* |