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Interaction between the dietary indices (DQI, DPI, HEI) and PPAR-γ gene variants on cardiovascular risk factors in a patient with type 2 diabetes mellitus
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  • Faezeh Abaj,
  • Gity Sotoudeh,
  • Elmira Karimi,
  • Masoumeh Rafiee,
  • Fariba Koohdani
Faezeh Abaj
Tehran University of Medical Sciences

Corresponding Author:[email protected]

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Gity Sotoudeh
Tehran University of Medical Sciences
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Elmira Karimi
Tehran University of Medical Sciences
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Masoumeh Rafiee
Isfahan University of Medical Sciences
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Fariba Koohdani
Tehran University of Medical Sciences
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Abstract

Background: We investigated the interaction between PPAR-γ Pro12Ala polymorphism and Healthy Eating Index (HEI), Dietary Quality Index-International (DQI-I) and Dietary Phytochemical Index (DPI) on Cardiovascular Disease (CVD) risk factors in patients with type 2 diabetes mellitus (T2DM). Methods: This cross-sectional study was conducted on 393 diabetic patients. PPAR-γ Pro12Ala was genotyped by PCR-RFLP method. Biochemical markers including total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), superoxide dismutase (SOD), C-reactive protein (CRP), total antioxidant capacity (TAC), pentraxin-3 (PTX3), isoprostaneF2α (PGF2α) were measured by standard protocol. FFQ was used for dietary indices (DQI, DPI, HEI) calculation. Results: There was no significant relationship between PPAR-γ Pro12Ala polymorphism and CVD risk factors. The rs1801282-DQI interactions were significant on WC (P= 0.01). Thus, C-allele carriers in the higher tertile of DQI had higher WC compared to GG homozygous. Further, an interaction was observed between PPAR rs1801282 polymorphism and DQI on serum IL-18 level (P = 0.03). Besides, a significant rs1801282-DPI interaction was shown on HDL concentration (P Interaction= 0.04), G allele carriers who were in the highest tertile of DPI, had lower HDL. Moreover, there were significant rs1801282-HEI interactions on ghrelin (P= 0.04) in the crude model and serum leptin (P = 0.02) in the adjusted model. Individuals with (CC, CG) genotypes in the higher tertile of HEI, had lower leptin and ghrelin concentration. Conclusions: Higher dietary indices (DQI, DPI, HEI) may affect the relationship between PPAR-γ Pro12Ala polymorphism and waist circumference and ghrelin, leptin, HDL-c, IL-18 concentration in patients with T2DM. To date, studies on this polymorphism have been shown that this gene can interact with diabetes and different nutritional factors. For the first time, this study provides information on the interaction of dietary indices (DQI, DPI, HEI) and PPAR-γ gene which is functionally effective in nutrient metabolism.
25 Nov 2020Submitted to International Journal of Clinical Practice
30 Nov 2020Submission Checks Completed
30 Nov 2020Assigned to Editor
27 Dec 2020Reviewer(s) Assigned
10 Jan 2021Review(s) Completed, Editorial Evaluation Pending
27 Feb 20211st Revision Received
27 Feb 2021Submission Checks Completed
27 Feb 2021Assigned to Editor
07 Mar 2021Reviewer(s) Assigned
16 Mar 2021Review(s) Completed, Editorial Evaluation Pending
27 Apr 2021Editorial Decision: Accept