Conclusion
To the authors’ knowledge, this is the first study presenting the association of a genetic variant of Cav-1 rs3807992 with the risk of MetS and its components, including TG, BP, and HDL level. However, further studies are needed to determine the strength of this association in a larger population; the contribution of this study is the novel finding that rs3807992 clearly predicts MetS among obese women. Analyses of the individual components of MetS confirmed that the rs3807992 variant is related to elevated BP, dyslipidemia, low HDL cholesterol, and high TG levels. Also, Cav-1 rs3807992 genotypes are sensitive to dietary SFA and PUFA, which allows individuals to monitor and adjust SFA and PUFA consumption accordingly. Finally, these results can be used in combination with a patient’s genetic history in order to provide more applicable and tailored nutritional advice for preventing or attenuating MetS in overweight and obese women.
Acknowledgments :
We would like to thank all the individuals who participated in this project. This study was supported by a grant from Tehran University of Medical Sciences (97-03-161-41017)
Conflict of Interest :
The authors declare no conflict of interest