Conclusion
To the authors’ knowledge, this is the first study presenting the
association of a genetic variant of Cav-1 rs3807992 with the risk of
MetS and its components, including TG, BP, and HDL level. However,
further studies are needed to determine the strength of this association
in a larger population; the contribution of this study is the novel
finding that rs3807992 clearly predicts MetS among obese women. Analyses
of the individual components of MetS confirmed that the rs3807992
variant is related to elevated BP, dyslipidemia, low HDL cholesterol,
and high TG levels. Also, Cav-1 rs3807992 genotypes are sensitive to
dietary SFA and PUFA, which allows individuals to monitor and adjust SFA
and PUFA consumption accordingly. Finally, these results can be used in
combination with a patient’s genetic history in order to provide more
applicable and tailored nutritional advice for preventing or attenuating
MetS in overweight and obese women.
Acknowledgments :
We would like to thank all the individuals who participated in this
project. This study was supported by a grant from Tehran University of
Medical Sciences (97-03-161-41017)
Conflict of Interest :
The authors declare no conflict of interest