Inclusion criteria
1. Original studies of adult patients (≥18 years old) with primary
biliary cholangitis, studies reporting generic or disease-specific HRQOL
questionnaires as outcome measure.
2. The study had to be a randomized controlled trial, cohort study, case
control study, clinical trial, or validation study of HRQL instruments.
3.Articles published between January 1999 and January 2020 (The
publication period of 20 years considered for this systematic review is
defined based on the reference list from Osborne et
al.)[9].