Questionnaires Scale (item) Domains description Scoring/administration
Disease-specific quality of life questionnaires
PBC-40[17]
6(40)
Fatigue, emotional, social, cognitive, itch and symptoms
5 point scale,1(not at all) to 5(very much) Total and subscale score Higher score indicates poorer health
PBC-27[12]
7(27)
Other Symptoms, dryness, itch, fatigue, cognitive, emotional and social
5 point scale,1(not at all) to 5(very much) Total and subscale score Higher score indicates poorer health
PBC-10[15]
6(10)
Fatigue, emotional, social, cognitive, itch and symptoms
5 point scale,1(not at all) to 5(very much) Total and subscale score Higher score indicates poorer health
CLDQ[18]
6(29)
Abdominal symptoms, fatigue, systemic symptoms, activity , emotional function, worry
7 point scale,1(not at all) to 7(very much) Total and subscale score Higher score indicates poorer health
CLDQ-I[19]
6(28)
Abdominal symptoms, fatigue, systemic symptoms, activity , emotional function, worry
6 point scale,1(not at all) to 7(very much) Total and subscale score Higher score indicates poorer health
LDSI 2.0[20]
18
Itch, joint pain, pain in the right upper abdomen, sleepiness during the day, worry about family situation, decreased appetite, depression, fear of complications and jaundice, nine other items measure the hindrance of these symptoms to daily activities
5 point scale,1(not at all) to 5(to a high extent) Subscale score Higher score indicates poorer health
Generic quality of life questionnaires
SF-36[21]
8(36)
Physical functioning, physical role functioning, limitation emotional role limitation, bodily pain, mental health, social functioning, vitality and general health perception
100 point scale,0(not at all) to 100(very much) Total and subscale score Higher score indicates greater health
SF-12[22]
2(12)
Physical component and mental summary
100 point scale,0(not at all) to 100(very much) Total and subscale score Higher score indicates greater health
15D(generic)[23]
15
Breathing, mental function, speech (communication), vision, mobility, usual activities, vitality, hearing, eating, elimination, sleeping, distress, discomfort and symptoms, sexual activity, and depression
5 point scale,1(not at all) to 5(very much) Total score Higher score indicates poorer health
NIDDK LTD-QOL[24]
5(21)
Measures of disease, psychological status, personal function, social and role function, and general health perception
5 point scale,0(not at all) to 4(extremely) Total and subscale score Higher score indicates poorer health
NIDDK-QA[16]
4(47)
Liver disease symptoms, physical functioning, health satisfaction and overall well-being
5 point scale,0(not at all) to 4(extreme) Total and subscale score Higher score indicates greater health
HUI-Mark-2[25]
7(15)
Sensation, mobility, emotion, cognition, selfcare, pain and fertility
2 point scale,0(not at all) to 1(very much) Total and subscale score Higher score indicates greater health
HUI-Mark-3[26]
8(15)
Vision, hearing, speech, ambulation, dexterity, emotion, cognition and pain 2 point scale,0(not at all) to 1(very much) Total and subscale score Higher score indicates greater health
NHP[27]
6(38)
Energy, sleep, pain, emotional reactions, social isolation, and physical mobility
2 point scale,0(no) to 1(yes) Total and subscale score Higher score indicates poorer health
NHANES Ⅲ (https://wwwn. 90 cdc.gov/nchs/nhanes/nhanes3/default.aspx)
4(83)
Articular symptoms, activity limitations (in both household and job-related activities), hobbies and leisure activities, and social life Total and subscale score Higher score indicates poorer health
PROMIS-29(generic)[28]
7(29)
Physical function, depression, anxiety, fatigue, sleep disturbance, ability to participate in social roles and activities (social roles), pain interference, and one pain intensity item
5 point scale,1(not at all) to 5(very much) Total and subscale score Higher score indicates poorer health