Author No. of patients Tumor Volume Dose (Gy) Median follow up (Months) Local Control (%) Overall Survival (%) Toxicity
Yuliang Jiang (2010)41 14 (3 NPC)
32(9.1-290.4)
157.5(90-218)
12(3-60)
Median 18mo 1y 52% 3y 39% 5y 39% Median 20mo 1y 65% 3y 39% 5y 39%
1 case mucosal reaction
Lihong Zhu (2013)42 19 (1 NPC)
20(1-270)
131(90-160)
11(3-44)
Median 24mo 1y 73.3% 2y 27.5% 3y 27.5% Median 13mo 1y 53.0% 2y 18.2% 3y 18.2%
1 case skin reaction
Xinying Shen (2015)43
30
Diameter 2.5±1.2cm (1.0-5.9)
130 (90-160)
2-38
1y 73.7% 2y 26.3% 3y 5.3% 1y 80.0% 2y 30.0% 3y 6.7%
NR
Hai Huang (2016)44 31 (9 NPC)
Mean 21.23 ± 8.83 cm2
Mean 101.03 ± 8.54 (90–125)
Range 6-38
1y 64.51% 2y 45.16% 1y 67.74% 2y 45.16% 3 cases G1 2 cases G2
Huzheng Yan (2017)45 81 (39 RSI-BT)
NR
120(100-140)
30(5-68)
1y 71.7% 2y 41.0% 3y 23.1% 1y 84.6% 2y 51.3% 3y 30.7% ≥G3 25.6% No G5
Zhe Ji (2018)40 101 (28 NPC)
15.5(2.4-99.4)
117 (44-246)
12.2(2.9-73.2)
5y 26.6%
5y 15.5%
7.9% G3 2% G4
Ping Jiang (2019)46 64 (12 NPC)
Mean 8cc(2.5-320)
130(90-160)
14(1-103.5)
1y 75.2% 3y 73.0% 5y 69.1% 1y 57.4% 3y 31% 5y 26.6%
2 cases of G4 skin reaction; 17% G1-2 skin reaction