Web interface development
The front end of VIP-HL is written in HTML5 and JavaScript (VUE), with the back end implemented in JAVA and Python 3. Uploaded variants are annotated via Ensembl Variant Effect Predictor (McLaren et al., 2016). A total of 142 hearing loss genes as mentioned above were collected from the ClinGen website (DiStefano et al. 2019). We pre-annotated all variants in these genes from ClinVar 20200629 release.