Conclusion
In this study, we demonstrate that social marginalization adversely impacts overall survival in endometrial cancer patients, independent of disease stage and other patient factors. Our study mitigates some of the confounders that commonly challenge health equity research in cancer care. Opportunities to reduce disparities in cancer outcomes exist across the entire disease trajectory, from prevention through early detection, access to care and healthcare utilization, treatment and survivorship. Further study is needed to identify targetable events in the cancer care pathway, and to assess the efficacy of healthcare systems interventions, in order to narrow the social chasm in cancer outcomes.