To date, there have only been 46 patients reported in the literature
with trisomy 18 and hepatoblastoma. We describe the case of an
11-month-old female with trisomy 18 and hepatoblastoma who was
successfully treated by pairing surgical resection with a modified
chemotherapy regimen omitting doxorubicin given her underlying cardiac
abnormalities. Our case successfully demonstrates how chemotherapy
regimens can be modified to accommodate for other underlying
abnormalities and emphasizes that routine screening guidelines should
exist for patients with trisomy 18 to allow for earlier detection and
treatment.