Randomisation, allocation concealment and blinding
Each individual study will be randomised. At randomisation each participant will be assigned to nebulised heparin or standard care. There is a one-to-one allocation ratio. Randomisation is stratified at the individual study level. Allocation concealment is performed at the level of each study. All studies are open label by design. The data analysts are blinded. Unblinding is permissible when pre-specified Bayesian stopping rules for efficacy or safety have been met.