Randomisation, allocation concealment and blinding
Each individual study will be randomised. At randomisation each
participant will be assigned to nebulised heparin or standard care.
There is a one-to-one allocation ratio. Randomisation is stratified at
the individual study level. Allocation concealment is performed at the
level of each study. All studies are open label by design. The data
analysts are blinded. Unblinding is permissible when pre-specified
Bayesian stopping rules for efficacy or safety have been met.