Correlation analysis of AD severity
Repeated measures correlation (R package: rmcorr) was applied to SCORAD and log2-transformed serum protein concentration across all years to account the dependent structure of the same patient over time for each marker and Benjamini-Hochberg multiple comparison adjustment across markers to report the correlation values and adjusted p -values [12]. Volcano plots were used to identify significant correlations (i.e., adjusted p -values <0.05 and repeated measures correlation >0.3 or <-0.3).