Periostin levels and asthma
Results of several previous childhood studies have demonstrated an
association between serum periostin levels and asthma. Song et al. (9)
have found that serum periostin levels were higher in children with
asthma and associated with airway hyperreactivity. Inoue et al (10).
have also found significantly higher serum periostin levels in children
with asthma compared to children without any allergic disease in their
cross-sectional study and they indicated the possible role of serum
periostin in the diagnosis of childhood asthma. On the other hand, Inoue
et al. (11) did not detect any increase in serum periostin levels in
school age children with allergic diseases including asthma in
comparison to healthy children. The serum periostin levels were found to
be significantly higher in children than those in healthy adults. They
have speculated that the high baseline levels of serum periostin due to
increased bone metabolism in childhood might have masked the possible
further increase due to allergic diseases. In our study serum periostin
levels were higher in children particularly with moderate and severe
asthma.