Multivariable regression and ROC analyses for severe asthma
Results of multivariable logistic regression analysis revealed that serum periostin levels were associated with severe asthma in children (OR, 1.10; 95% CI, 1.04-1.15; P <0.001) (Table 5).
Analysis using ROC curves identified the role of serum periostin levels in determining children with severe asthma (AUC: 0.77, 95% CI: 0.67–0.87, P < 0.001]. When analysed for the best cut-off value with the highest combined sensitivity and specificity, a cut-off value of 52 ng/ml for serum periostin level was obtained with sensitivity, specificity, PPV, and NPV of 100%, 50%, 29%, and 100%, respectively.