PMIS evaluation protocol
We used a three-stage evaluation protocol that was developed based on
information available on PMIS at the end of May 2020 and deduced from
Kawasaki’s syndrome. Children with strong antibody responses were asked
to contact their caring pediatrician or, in cases when this was not
possible, to approach study doctors being pediatric cardiologists and
Kawasaki experts. The first stage of evaluation included clinical
parameters: fever for three days or more, conjunctivitis,
lymphadenopathy, exanthema, enanthema, skin pealing, oedema/ erythema of
extremities, gastrointestinal problems, and arterial hypotension. The
second stage comprised laboratory investigations such as urine
examination for protein, leukocytes and erythrocytes and inflammatory
markers in blood. At the third stage, screening for blood coagulopathies
and cardiac effects (by echocardiography) were performed. The protocol
used for this evaluation is accessible online
(www.cokiba.we-care.de).