Atrial Appendage Morphology
The 284 subjects with appendage imaging consisted of patients in each of
the GRS quartile [L, n=71, LI, n=73, HI, n=69, and H, n= 71].
Baseline demographics were similar in age, gender, race (data not
shown). Figure 4A shows no differences in left atrial morphology (L:
46%; LI: 46%; HI 45%; H: 54%), os circumference (L: 2.40 ± 0.60; LI:
2.60 ± 0.61; HI 2.51 ± 0.62; H: 2.57 ± 0.58; p =0.21), or indexed volume
(L: 3.75 ± 0.81; LI: 3.80 ± 0.80; HI 3.70 ± 0.81; H: 3.82 ± 0.82; p
=0.31) as stratified by GRS quartile. Figure 4B Baseline demographics
showed no difference between carriers and non-carriers in age (C 61±8 vs
NC 60±9 years), gender (C 27% vs NC 37% female), race (C 84% vs NC
81% white), hypertension(C 34% vs NC 29%), diabetes(C 5% vs NC 8%),
coronary/vascular disease presence (C 12% vs NC 14%), heart failure
presence(C 8% vs NC 7%), body-mass index (C 28.8 ± 4.5 vs NC 29.7 ±
4.6 kg/m2), serum creatinine (C 0.91± 0.11 vs NC 0.89 ± 0.12 mg/dl),
percent paroxysmal AF (C 54% vs NC 52%) or calculated CHADVASC score
(cardioembolic score that does not include stroke; C 2.20 ± 0.50 vs 2.1
± 0.6). Of the 109 carrier patients, 89 (82%) had a non-CW morphology
and 20 (18%) had a CW morphology. In the non-carrier 175 patient
population, 47 (27%) had non-CW whereas 128 (73%) were CW. Carriers
also had smaller LAA orifice (2.20 ± 0.05 cm vs 2.79 ± 0.07 cm
; P < .01) however no change in LA diameter (C 4.2 ±
0.50 cm vs NC 4.79 ± 0.6 cm), LA indexed volume (C 34.7 ± 10.2 vs NC
36.3 ± 11.2 ml/m2), or LVEF (C 55 ± 5 vs NC 58 ± 7 %) were noted.
Carriers also had a larger volume of the LAA 4.10 ± 0.14 ml/m2 versus
non-carriers 3.59 ± 0.18 ml/m2; P < 0.01.