Introduction
Hereditary interstitial lung disease (HILD) associated with surfactant
protein C gene (SFTPC ) variation exhibits various phenotypes,
including asymptomatic adults or severe respiratory failure in
infancy.1 Although several case reports have shown
success with hydroxychloroquine (HCQ) treatment, other factors that can
predict treatment responsiveness or disease prognosis remain largely
unknown. Improvement of oxygenation was often used as a clinical
parameter,2 but it is difficult to evaluate the
oxygenation under specific oxygen concentrations when using conventional
oxygen therapy in young children.3 Especially for
patients with HILD, the oxygen concentration via a nasal cannula can
vary due to respiratory distress. Here, we report that a high-flow nasal
cannula (HFNC) was useful for clinical evaluation in the case of HILD
with SFTPC variation.