Abstract:
SARS-CoV-2 infections have presented with numerous neurological
manifestations, providing insight into the potential of SARS-CoV-2 virus
in triggering autoantibody production and dysregulating the immune
system. We report the case of a young obese lady, recently discharged
after treatment for COVID-19, who later presented with headache and
blurred vision, diagnosed to have pseudotumor cerebri and concurrent
bilateral optic neuritis. To the best of our knowledge, this is the
first case report to establish concurrent intracranial hypertension,
anti-MOG syndrome/neuromyelitis optical optica syndrome disorder (NMOSD)
and SARS-CoV-2 infection. The accumulative number of reports of COVID-19
patients with demyelinating manifestations such as bilateral optic
neuritis with clinical and radiological features of NMOSD/Anti-MOG
syndrome delineate that probable neuro-invasion is a reasonable concern
that SARS-CoV-2 is an emerging neuropathogen. Further experimental
models and research are warranted to better understand how the acute and
chronic course of illness in the context of SARS-CoV-2 could further
modulate our approach and treatment.