2.CD200-R inhibitors role in coronavirus infection:
Molecular studies indicated that some pathogens bypass the host cell’s immune system by exploiting CD200: CD200-R signaling pathway. The animal studies in mice showed that type 1 interferon (IFN 1) production in response to TLR-7 signaling has a key role in coronavirus clearance, and the CD200: CD200-R suppression prevents virus clearance by limiting IFN1 production (16). So, Using CD200 signaling inhibitors like Samalizumab in the early stages of Covid-19 infection might help restrict the virus invasion. Further clinical studies are necessary to make a conclusion on CD200 inhibitors efficacy in limiting specific viral infections as they are novel agents that generally have not been involved in long term clinical trials, and supportive details of using these agents are lacking.