1.Evidence of the dysregulated immune response in COVID-19
infection:
A cohort study of 452 patients with laboratory-confirmed COVID-19 in
Wuhan, China, reported a dysregulated immune response in these patients.
As a result of this suppressed immune response, the increase of
neutrophil to lymphocyte ratio (NLR), T lymphopenia, and decrease of
CD4+ T cells were considered as common laboratory findings, especially
in severe cases. However, there was no significant change in the number
of CD8+ cells and B cells. According to these data, lymphocyte damage,
especially T lymphocytes, seems to be one of the most important disease
pathogenesis factors. It is suggested that the amount of lymphocyte
injury (mainly T lymphocyte) and subsequent cellular immune suppression
are a critical factor in disease
progression(14).
Furthermore, another study in Wuhan, China, also confirmed the
relationship between T cell count and disease prognosis. According to
this research, patients with a total T cell count lower than 800/µl
generally require more aggressive interventions and ICU
admission(15).