A, Change in mean amplitude of glucose excursions (MAGE; mmol/L) in response to MET+INS vs INS.

B, Change in standard deviation of blood glucose (SDBG; mmol/L) in response to MET+INS vs INS.

C, Change in largest amplitude of glycemic excursions (LAGE; mmol/L) in response to MET+INS vs INS.

D, Change in coefficient of variation (CV; %) in response to MET+INS vs INS.