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\begin{document}

\title{Risk of skin erosion and local pocket infections in population of
patients with cardiac implantable electronic devices undergoing
transvenous lead extraction}



\author[1]{Anna Polewczyk}%
\author[2]{Wojciech Jacheć}%
\author[3]{Andrzej Kutarski}%
\affil[1]{Jan Kochanowski University of Kielce Collegium Medicum}%
\affil[2]{Medical University of Silesia in Katowice, School of Medicine with the Division of Dentistry in Zabrze}%
\affil[3]{Medical University of Lublin}%


\vspace{-1em}



  
  \date{May 15, 2024}


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\selectlanguage{english}
\begin{abstract}
The thinning of the skin over the pocket is an occasional phenomenon in
patients with cardiac implantable electronic devices (CIEDs) most often
associated with the technique of implantation of the device. It is
likely that the thinning of the skin over the generator is a risk factor
for the development of infectious complications in patients with CIED.
Analysis of large database of 3706 patients undergoing transvenous lead
extraction (TLE) showed higher number of points of PADIT score and more
often previous pocket plastic surgery in patients with too shallow
pocket. Most likely, diagnosing only a too shallow CIED pocket is often
an early symptom of infection.%
\end{abstract}%



\sloppy


\textbf{Risk of skin erosion and local pocket infections in population
of patients with cardiac implantable electronic devices undergoing
transvenous lead extraction}

\selectlanguage{polish}\textbf{Authors: Anna Polewczyk (1,2), Wojciech Jacheć (3), Andrzej
Kutarski (4)}\selectlanguage{english}

Department of Physiology, Pathophysiology and Clinical Immunology,
Collegium Medicum of Jan Kochanowski University, Kielce, Poland (1),
Department of Cardiac Surgery, Swietokrzyskie Cardiology Center, Kielce,
Poland (2), 2nd Department of Cardiology, Zabrze, Faculty of Medical
Science in Zabrze, Medical University of Silesia in Katowice, Poland
(3), Department of Cardiology, Medical University of Lublin Poland (4)

Funding: None

Disclosures: None

\par\null

\textbf{Corresponding author} :

Anna Polewczyk MD, PhD

Collegium Medicum of Jan Kochanowski University

5, \selectlanguage{polish}Ż\selectlanguage{english}eromskiego St. 25-369 Kielce, Poland

\emph{annapolewczyk@wp.pl}

Phone number +48600024074

\textbf{Abstract}

The thinning of the skin over the pocket is an occasional phenomenon in
patients with cardiac implantable electronic devices (CIEDs) most often
associated with the technique of implantation of the device. It is
likely that the thinning of the skin over the generator is a risk factor
for the development of infectious complications in patients with CIED.
Analysis of large database of 3706 patients undergoing transvenous lead
extraction (TLE) showed higher number of points of PADIT score and more
often previous pocket plastic surgery in patients with too shallow
pocket. Most likely, diagnosing only a too shallow CIED pocket is often
an early symptom of infection.

\textbf{Editorial}

The thinning of the skin and subcutaneous tissue above the pocket of
cardiac implantable electronic devices (CIED) is an is an occasional
phenomenon, which may have many reasons. The most frequently considered
are: improper CIED implantation or re-implantation with too shallow
design of the pocket, progressive weight loss (cachexia), but it can
also be the temporary first visible stage or even first symptom of CIED
pocket infection. In the observation of Yatomi et al. risk factors for
skin thinning over the generator were: low BMI, low haemoglobin level,
heart failure, malignancy and renal dysfunction. In this study, a
retrospective analysis of clinical data from a group of 101 patients
with an average lead dwell time of 95 months revealed no cases of pocket
infections in patients with thinning of the skin over the generator.
Authors recognised thinning of the skin in 17 patients (about 17\%)
which indicates, that the phenomenon is not so rare. According to our
observations, too tight skin over a too tight and shallow pocket loses
its elasticity and becomes less and less mobile, and after some time,
progressive necrotic processes lead to a lack of protection against the
penetration of bacteria. Patients with a shallow CIED pocket should be
monitored by an electrocardiologist controlling the device (and
performing follow-up). Changes in the colour of the skin towards blue or
reddening, the appearance of pain or local warming, or the loss of skin
sliding over the bed, means the probable beginning of infection, which
is an indication for transvenous lead extraction (TLE). In patients with
a very superficial generator site, without signs of infection, the
possibility of deepening the pocket (so called surgical ``plastic of the
CIED pocket'') is sometimes considered. Theoretically, this type of
procedure is possible, but the extremely shallow location of the unit is
accompanied by the loop of the lead growing into the skin and the
preparation of such leads is often associated with risk of their
accidental damage as well as an increased risk of developing infectious
complications. It should be emphasized that an excessively shallow
pocket is not an indication for transvenous lead extraction. Its
consequence in the form of bedsores (limited skin necrosis) or the next
stage - purulent fistula over the pocket or loop of the lead - as an
infectious complication - is already an indication for TLE ( Figure 1,
Figure 2).

\textbf{Figure 1 Four examples of too shallow CIED pockets. A. Visible
growth of the lead loops into the skin. B one-way pressure of the
pacemaker housing against the wall of the pocket. C Onset of redness,
indicating that an infection may start. D. Possibly improperly performed
unit replacement; the tension of a to small pocket pushes the pacemaker
upwards.}

\textbf{Figure 2 Four examples of infections of too shallow CIED
pockets. The lead loop (A) or the edge of the unit (B, C, D) causes
progressive skin necrosis and secondary classic infection. Examples of
situations where it is much too late for surgical ''plastic pocket
surgery'' and the only solution is to remove the infected system
completely.}

In our large database of 3706 patients who underwent TLE in the years
2006-until now, 60 patients with too shallow pocket were identified. In
60\% of patients in this group, the main indication for TLE was
CED-related infection (in 30\% local, pocket infection). Among the
non-infectious indications, the dominant ones were: lead dysfunctions
caused by their mechanical damage and other causes (20\% in total).
Consistent with guidelines for indications for transvenous lead
extraction, a too shallow pocket is not the primary cause of TLE (Table
1).\selectlanguage{english}
\begin{longtable}[]{@{}lll@{}}
\toprule
\textbf{Table 1 Indications for TLE in 60 patients with thinning of the
skin and subcutaneous tissue above the pocket of CIED} &
&\tabularnewline
\midrule
\endhead
\textbf{Predominant indication for lead extraction - infective} &
&\tabularnewline
Lead related infective endocarditis certain & 12 &
20,00\%\tabularnewline
Lead related infective endocarditis probable & 6 &
10,00\%\tabularnewline
Local (pocket) infection & 18 & 30,00\%\tabularnewline
All & 36 & 60,00\%\tabularnewline
\textbf{Predominant indication for lead extraction - non-infective} &
&\tabularnewline
Mechanical lead damage (electric failure) & 6 & 10,00\%\tabularnewline
Lead dysfunction (exit/entry block, dislodgement, extracardiac pacing,
peroration) & 6 & 10,00\%\tabularnewline
Abandoned Lead / prevention of abandonment (AF, overmuch of leads) & 2 &
3,33\%\tabularnewline
Threatener / potentially threatener lead (loops, free ending, left
heart, LDTVD) & 1 & 1,67\%\tabularnewline
Other (MRI indication, cancer, pain of pocket, loss of indication for
pacing / ICD) & 7 & 11,67\%\tabularnewline
Recapture venous access (sympt. occlusion, SVC syndr., lead replacement
/ upgrading) & 2 & 3,33\%\tabularnewline
All & 24 & 40,00\%\tabularnewline
\bottomrule
\end{longtable}

A comparative analysis of clinical factors characterizing patients with
pocket thinning and patients with non-infectious indications for TLE
showed more frequent occurrence of a shallow pocket in elderly male
patients, with higher number of HAS-bleed score,. Patients with a
confirmed CIED-related infection more often had diabetes, higher
Charlson's co-morbidity index, higher inflammatory parameters and lower
hemoglobin levels (Table2).

\textbf{Table 2 Clinical characteristics of compared groups}\selectlanguage{english}
\begin{longtable}[]{@{}lllllllllllll@{}}
\toprule
\begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{Patient-related risk factors of infection and additional
clinical information}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{CIED pocket thinning} (mixed subgroup with co-existing another
indication for TLE)\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{CIED pocket thinning} (mixed subgroup with co-existing another
indication for TLE)\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{Noninfective TLE indications}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{Noninfective TLE indications}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{Pocket infection with or without LRIE}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{Pocket infection with or without LRIE}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{Isolated LRIE (without pocket infection)}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{Isolated LRIE (without pocket infection)}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{P} \textbf{1 vs 2}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{P} \textbf{1 vs 3}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{P} \textbf{1 vs 4}\strut
\end{minipage}\tabularnewline
\midrule
\endhead
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Number of patients / group number}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
60\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
2511\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
789\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
3\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
349\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Form of results presentation (count/average; Sd/\%)}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Count / average\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\%/Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Count / average\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\%/Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Count / average\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\%/Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Count / average\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\%/Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Patient's age during TLE}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
68,95\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12,56\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
64,77\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
16,38\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
69,51\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
13,23\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
66,38\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
14,27\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,05\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,45\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,19\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Patient's age during first system implantation}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
62,00\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
13,10\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
55,93\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
17,98\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
61,87\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
14,14\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
68,61\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
15,65\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,01\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,94\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0,01\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Sex (\% of male patients) (\%)}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
33\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
55,00\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1452\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
57,83\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
564\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
71,48\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
243\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
69,63\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,64\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0,01\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,03\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Underlaying heart disease: IHD, MI}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
35\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
58,33\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1410\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
56,15\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
442\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
56,02\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
177\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
50,72\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,71\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,70\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0,01\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{NYHA III \& IV}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
6,67\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
354\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
14,10\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
104\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
13,18\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
99\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
28,37\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,10\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,14\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,18\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Congestive heart failure (symptomatic presently)}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
5\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8,33\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
488\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
19,43\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
118\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
14,96\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
84\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
24,07\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,04\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,15\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,58\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{LVEF average (\%)}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
49,73\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
14,13\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
49,99\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
15,46\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
48,520\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
14,64\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
47,37\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
15,45\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,90\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,54\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,26\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{LVEF significantly limited / decreased / reduced
(\textless{}30\%)}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
7\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
11,67\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
304\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12,1\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
104\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
13,18\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
55\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
15,76\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,90\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,71\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,41\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Renal failure (any)}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
20,00\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
465\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
18,52\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
181\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
22,94\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
133\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
38,11\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,76\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,60\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,51\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Diabetes (any)}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
7\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
11,67\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
452\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
18,00\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
179\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
22,69\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
101\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
28,94\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,21\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,05\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,81\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Malignancy in history}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
6,67\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
160\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
6,37\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
48\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
6,08\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
26\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
7,45\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,91\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,84\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,17\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Treatment with steroids in history}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,00\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
29\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,15\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
18\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
2,28\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
15\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4,30\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,40\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,23\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,26\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Permanent AF presence}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
20,00\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
536\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
21,35\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
206\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
26,11\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
89\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
25,50\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,80\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,27\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,05\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Mechanical valve presence}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,67\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
132\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
5,26\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
35\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4,44\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
15\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4,30\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,21\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,28\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,88\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Long-term anticoagulation was necessary}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
26\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
43,33\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
982\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
39,11\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
290\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
36,76\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
146\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
41,83\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,49\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,29\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,29\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Long-term antiplatelet therapy in recent history}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
29\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
48,33\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1055\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
42,02\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
342\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
43,35\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
150\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
42,98\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,31\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,46\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0,01\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{CHA2DS2--VASc scale - number of points}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
3,20\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,01\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
2,90\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,73\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
3,19\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,67\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
3,17\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,75\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,18\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,96\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,90\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{HAS-BLED scale - number of points}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,73\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,01\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,34\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,03\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,62\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,02\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,64\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,16\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0,01\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0,01\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0,01\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Charlson's co-morbidity index - number of points}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4,28\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
3,05\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4,48\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
3,62\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
5,13\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
3,63\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
5,56\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4,02\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,67\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,08\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,02\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{BMI}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
27,65\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4,66\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
27,95\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
5,74\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
27,72\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
3,87\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
27,65\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4,48\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,69\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,08\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,00\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{CRP level}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
15,56\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
34,90\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
10,67\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
24,65\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
29,09\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
43,45\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
75,40\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
77,84\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,13\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,02\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0,01\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{WBC (thousands)}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8,22\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
2,82\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
7,73\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
3,41\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8,37\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
3,33\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
11,08\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
6,25\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,27\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,73\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0,01\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Haemoglobin}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
13,03\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,79\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
13,28\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,76\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12,68\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,88\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
11,26\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
2,14\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,28\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,16\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0,01\strut
\end{minipage}\tabularnewline
\bottomrule
\end{longtable}

Abbreviations: CIED- cardiac implantable electronic device, CRP-
C-reactive protein, LRIE- lead related infective endocarditis, LVEF-
left ventricular ejection fraction, TLE- transvenous lead extraction,
WBC- white blood count

Thinning of the pocket was more often observed in patients with higher
number of leads and higher number of CIED-related procedures before TLE
especially surgical plastic surgery. This group of patients was also
characterized by shorter lead dwell time, shorter time since last
CIED-related procedure and higher score on the PADIT scale ( Table 3).

\textbf{Table 3. System- related and history of pacing- related risk
factors of CIED complications in compared groups}\selectlanguage{english}
\begin{longtable}[]{@{}lllllllllllll@{}}
\toprule
\begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{System-related risk factors of CIED-related complications}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{CIED pocket thinning} (mixed subgroup with co-existing another
indication for TLE)\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{CIED pocket thinning} (mixed subgroup with co-existing another
indication for TLE)\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{Non-infective TLE indications}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{Non-infective TLE indications}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{Pocket infection with or without LRIE}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{Pocket infection with or without LRIE}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{Isolated LRIE (without pocket infection)}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{Isolated LRIE (without pocket infection)}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{P} \textbf{1 vs 2}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{P} \textbf{1 vs 3}\strut
\end{minipage} & \begin{minipage}[b]{0.07\columnwidth}\raggedright\strut
\textbf{P} \textbf{1 vs 4}\strut
\end{minipage}\tabularnewline
\midrule
\endhead
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Number of patients / group number}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{60}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{1}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{2511}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{2}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{789}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{3}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{349}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{4}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Units}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Count / average}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{\%/Sd}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Count / average}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{\%/Sd}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Count / average}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{\%/Sd}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Count / average}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{\%/Sd}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Kind of CIED system}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Kind of CIED system}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Kind of CIED system}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Kind of CIED system}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Kind of CIED system}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Kind of CIED system}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Kind of CIED system}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Kind of CIED system}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Kind of CIED system}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Kind of CIED system}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Kind of CIED system}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Kind of CIED system}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Kind of CIED system}\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Pacemaker}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
42\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
70,00\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1796\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
71,53\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
559\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
70,85\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
235\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
67,34\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,79\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,87\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,66\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{ICD}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
20,00\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
573\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
22,82\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
151\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
19,14\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
80\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
22,92\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,61\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,86\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,61\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{CRT-D}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
6\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
10,00\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
142\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
5,66\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
79\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
10,01\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
34\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9,74\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,15\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,99\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,95\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{History of pacing}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{History of pacing}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{History of pacing}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{History of pacing}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{History of pacing}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{History of pacing}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{History of pacing}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{History of pacing}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{History of pacing}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{History of pacing}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{History of pacing}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{History of pacing}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{History of pacing}\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Number of leads in the heart before TLE before TLE}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
2,08\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,74\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,89\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,71\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
2,06\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,75\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
2,13\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,87\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,04\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,84\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,67\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{4 and \textgreater{} 4 in the heat before TLE}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
6,67\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
52\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
2,07\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
39\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4,94\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
22\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
6,30\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,02\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,54\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,77\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Number of CIED-related procedures before lead extraction}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,98\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,93\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,72\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,96\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
2,24\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,25\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,93\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1,25\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0,01\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,11\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,49\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Presence of abandoned lead before TLE n (\%)}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
13,33\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
221\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8,80\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
132\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
16,73\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
52\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
14,90\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,21\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,49\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,72\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Time since last CIED-related procedure (any)}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
28,53\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
31,75\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
51,42\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
37,06\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
31,27\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
29,43\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
44,54\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
36,15\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0,01\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,49\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0,01\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Surgical plastic of unit pocket in history}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
n (\%)\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
3,33\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
13\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,52\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
202\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
25,60\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
16\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4,58\%\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0,01\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0,01\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,63\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Dwell time of oldest one lead in the patient {[}months{]}}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
84,12\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
65,59\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
106,6\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
78,58\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
92,57\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
69,81\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
93,94\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
72,06\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,03\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,36\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,32\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Mean lead dwell time before TLE mean {[}months{]}}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
77,22\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
59,51\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
99,55\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
69,79\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
82,26\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
60,04\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
85,34\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
61,29\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,01\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,53\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,34\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Cumulative dwell time of extracted lead (in years) in the
patient}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12,86\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9,8\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
15,77\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
13,14\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
14,04\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
11,51\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
15,94\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
14,79\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,09\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,44\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,12\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textbf{Risk of infection -- PADIT calculation - number of points}\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Aver\selectlanguage{ngerman}±Sd\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4,13\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
3,21\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
3,37\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
2,82\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4,16\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
3,04\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
4,01\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
2,93\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,04\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,094\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0,77\strut
\end{minipage}\tabularnewline
\bottomrule
\end{longtable}

Abbreviations: CIED- cardiac implantable electronic device, CRT- cardiac
resynchronization therapy, ICD- implantable cardioverter defibrillator,
LRIE- lead related infective endocarditis, TLE- transvenous lead
extraction, WBC- white blood count

Current analysis of a very large database of patients undergoing TLE
confirmed the clinical importance of thinning of the CIED pocket in the
development of infectious complications.

Patients with pocket infections (with or without lead-related
endocarditis) were more often undergoing surgical plastic surgery before
TLE (27\%). This clearly indicates that previously recognized only too
shallow CIED pockets were already an early symptom of an infection
which, despite the deepening of the pocket, developed into a full-blown
infection after some time. Despite the fact that in the group of
patients with a shallow pocket of the CIED, only 60\% of patients had an
infection, the highest values of the PADIT score were recorded in this
group of patients. These observations suggest the possibility of an
earlier development of microorganisms in a too shallow pockets. Previous
studies based on small populations confirm the presence of early
contamination of the pocket with a tendency to subsequent colonization
and development of full-blown infection. It seems that in patients with
a shallow pocket, the infectious process may begin early after
implantation and proceed covertly, therefore, presented by Yatomi et al.
the concept of measuring skin thinning over the generator can be a form
of detailed control of patients particularly at risk of developing
infectious complications..

References

\begin{enumerate}
\tightlist
\item
  Kusumoto FM, Schoenfeld MH, Wilkoff B, Berul CI, Birgersdotter-Green
  UM, Carrillo R, Cha YM, Clancy J, Deharo JC, Ellenbogen KA Exner D,
  Hussein AA, Kennergren C, Krahn A, Lee R, Love CJ, Madden RA, Mazzetti
  HA, Moore JC, Parsonnet J, Patton KK, Rozner MA, Selzman KA, Shoda M,
  Srivathsan K, Strathmore NF, Swerdlow CD, Tompkins C, Wazni O. 2017
  HRS expert consensus statement on cardiovascular implantable
  electronic device lead management and extraction. Heart Rhythm
  2017;14:e503--e551
\item
  Okada M,~Kashiwase K, Hirata A, Nemoto T, Matsuo K, Murakami A, Ueda
  Y. Bacterial Contamination During Pacemaker Implantation Is Common and
  Does Not Always Result in Infection. Circ J. 2015;79:1712-1718
\item
  Machino T, Sekiguchi Y. Positive Pocket Cultures From Cardiac
  Implantable Electrophysiological Devices Without Infection --
  Contamination or Colonization? Circ J. 2015;79:1680-1681
\item
  Goel R. Device Pocket Challenges in Elderly and Thin Individuals.
  Cureus. 2021; 25;13:e12902
\item
  Polewczyk A, Jache\selectlanguage{polish}ć \selectlanguage{english}W, Polewczyk AM, Tomasik A, Janion M, Kutarski A.
  Infectious complications in patients with cardiac implantable
  electronic devices: risk factors, prevention, and prognosis. Pol Arch
  Intern Med. 2017; 29:597-607
\item
  Birnie DH, Wang J, Alings M, Philippon F, Parkash R, Manlucu J,
  Angaran P, Rinne C, Coutu B, Low RA, Essebag V, Morillo C, Redfearn D,
  Toal S, Becker G, Degr\selectlanguage{ngerman}âce M, Thibault B, Crystal E, Tung S, LeMaitre
  J, Sultan O, Bennett M, Bashir J, Ayala-Paredes F, Gervais P, Rioux L,
  Hemels MEW, Bouwels LHR, Exner DV, Dorian P, Connolly SJ, Longtin Y,
  Krahn AD. Risk Factors for Infections Involving Cardiac Implanted
  Electronic Devices. J Am Coll Cardiol . 2019; 10:2845-2854
\end{enumerate}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/Figure-1/Figure-1}

\end{center}
\end{figure}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/Figure-2/Figure-2}

\end{center}
\end{figure}

\selectlanguage{english}
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\end{document}

