Sample size and study population
We calculated minimum sample size as 84 patients with an effect size of 0.4, type 1 error of 0.05, and a power of 0.90 for ANOVA testing of three groups using GPower 3.1 software.
A total of 96 patients (53 men, 38 women) aged 18 years and older who were followed up for CCHF in the Erzurum Regional Training and Research Hospital Department of Infectious Diseases were included in the study. Patients who developed bacterial superinfection confirmed by blood, sputum, and urine cultures during CCHF follow-up and patients who were pregnant, had known malignancies, had liver or kidney failure, used anti-inflammatory drugs in the last month, or were followed up for acute coronary syndrome in the last 2 months were excluded.