Statistical analysis
Continuous data are reported as mean ± standard deviation or median (interquartile range [IQR]) depending on their distribution. Categorical data are presented as frequencies (percentages). Comparative analyses involved the Wilcoxon matched-pairs signed rank test. Complete data were available for all patients. Statistical analyses were performed with JMP v9 (SAS Institute Inc., Cary, NC) and PRISM v7 (GraphPad, San Diego, CA).