Figure
2
Figure 2. Schematic representation of SARS-CoV-2 entry and
replication in host cells. SARS-CoV-2 enters host cells through its
spike ‘S’ protein by interacting with host’s ACE-2 receptor where S is
primed by the host cell serine protease, TMPRSS2. Upon entry, release of
viral genomic RNA subsequently leads to genomic replication by using
host cell’s translational and transcriptional machineries. Structural
proteins are synthesized and assembled at Endoplasmic reticulum (ER) and
Golgi apparatus (GA) respectively, followed by their maturation and
release.