Conclusion
The COVID-19 pandemic has prompted numerous research studies to investigate its pathology and the potential therapies that could be effective against this virus. The various studies discussed in this article present different theories concerning SARS-CoV-2 progression and some tie it to mitochondrial processes. Overall, these articles have demonstrated that the manipulation of host mitochondria by SARS-CoV-2 is an integral part of its success in replication and disease progression through modulating various functions (Figure 4) . Further research on how SARS-CoV-2 hijacks mitochondrial functions to replicate and suppress the immune system would provide insight into novel therapy and prevention. Specifically, research should be conducted on how the virus localizes RNA in the host mitochondria and why this localization aids with the progression of the infection. Moreover, mitochondrial ties to the ACE-2 receptor and whether this receptor is more harmful than beneficial for the host should be further researched as well due to a lack of clear clinical evidence. Investigating the interactions between mitochondrial and viral proteins and how they could be prohibited would provide insight into better treatment options as well. Furthermore, ties to aging and gender should be examined to produce therapies that are better catered for those demographics. Studying these topics would ultimately provide a better understanding of not only SARS-CoV-2 but of any similar future viruses, which can facilitate the breakthrough of more successful treatment and prevention approaches.
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