Conclusion
The COVID-19 pandemic has prompted numerous research studies to
investigate its pathology and the potential therapies that could be
effective against this virus. The various studies discussed in this
article present different theories concerning SARS-CoV-2 progression and
some tie it to mitochondrial processes. Overall, these articles have
demonstrated that the manipulation of host mitochondria by SARS-CoV-2 is
an integral part of its success in replication and disease progression
through modulating various functions (Figure 4) . Further
research on how SARS-CoV-2 hijacks mitochondrial functions to replicate
and suppress the immune system would provide insight into novel therapy
and prevention. Specifically, research should be conducted on how the
virus localizes RNA in the host mitochondria and why this localization
aids with the progression of the infection. Moreover, mitochondrial ties
to the ACE-2 receptor and whether this receptor is more harmful than
beneficial for the host should be further researched as well due to a
lack of clear clinical evidence. Investigating the interactions between
mitochondrial and viral proteins and how they could be prohibited would
provide insight into better treatment options as well. Furthermore, ties
to aging and gender should be examined to produce therapies that are
better catered for those demographics. Studying these topics would
ultimately provide a better understanding of not only SARS-CoV-2 but of
any similar future viruses, which can facilitate the breakthrough of
more successful treatment and prevention approaches.
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