DOES THE INTRATYMPANIC APPLICATION OF MESNA PREVENT THE CHOLESTEATOMA?
AN EXPERIMENTAL RATS STUDY
Purpose Studying the effect of Mesna on middle ear otitis media and
cholesteatoma induced by propylene glycol on an experimental animal
model. Methods The study was designed to consist of sixteen Wistar
albino rats, their right ears being the control group and left ears
being the experiment group. %50 propylene glycol, gentamicinsulfate and
physiologic salt water were applied to the right ear and %50 propylene
glycol, gentamicinsulfate and %20 Mesna were administered to the left
ear through intratympanic injections on days 1, 3, 8, 15 and 21. The
rats were sacrificed 45 days after the first injection and underwent
histopathological examination. Results It was seen that cholesteatoma
and fibrosis were less common in the experiment group in microscopic
evaluation. A statistically significant decrease was observed when the
average and maximum thicknesses of the tympanic membranes and the
minimum thicknesses of the tympanic bulla of the control group and the
experiment group were compared. (p< 0.05) Conclusion In the
experimental cholesteatoma model created in rats, no statistical
significance was observed, indicating that Mesna, which was applied
intratympanically, completely prevented the formation of cholesteatoma.
However, it was found that the prevalence of cholesteatoma formation was
microscopically less in the experimental group.