SARS coronavirus 2 (SARS - CoV - 2) in the viral spike (S) encoding a SARS - COV - 2 SPIKE D614G mutation protein predominate over time in locales revealing the dynamic aspects of its key viral processes where it is found, implying that this change enhances viral transmission. In this paper, we strongly combine topology geometric methods for generalized formalisms of k - nearest neighbors as a Tipping–Ogilvie and Machine Learning application within the quantum computing context targeting the atomistic level of the protein apparatus of the SARS - COV - 2 viral characteristics. In this effort, we propose computer - aided rational drug design strategies efficient in computing docking usage, and powerful enough to achieve very high accuracy levels for this in - silico effort for the generation of AI - Quantum designed molecules of GisitorviffirnaTM, Roccustyrna_gs1_TM, and Roccustyrna_fr1_TM ligands targeting the COVID - 19 - SARS - COV - 2 SPIKE D614G mutation by unifying Eigenvalue Statements into Shannon entropy quantities as composed on Tipping–Ogilvie driven Machine Learning potentials for nonzero Christoffel symbols for Schwarzschild (DFT) ℓneuron (ι) : == == φ∘D∘r2∘S∘r102 (1+∑) == == (A∧A’ (p)) • ⋱⋯⊗⋱⋯ •e− ρ (rr) −−¯σ − ¯σσ¯ǫ −i_+02 (1− ) 2} () ) improver for Chern - Simons Topology Euclidean Geometrics. I also arrived at a new Zmatter derived finite ‐ dimensional state integral with a symplectic ω == == (i~)−1 (dx/x) ∧ (dy/y) model for computing the analytically continued “holomorphic blocks” on an appropriate quantum Hilbert space H that compose physical Chern ‐ Simons partition function to put pharmacophoric elements back together.
SARS coronavirus 2 (SARS-CoV-2) in the viral spike (S) encoding a SARS-COV-2 SPIKE D614G mutation protein predominate over time in locales revealing the dynamic aspects of its key viral processes where it is found, implying that this change enhances viral transmission. It has also been observed that retroviruses infected ACE2-expressing cells pseudotyped with SG614 that is presently affecting a growing number of countries markedly more efficiently than those with SD614. In this paper, we strongly combine topology geometric methods targeting at the atomistic level the protein apparatus of the SARS-COV-2 virus that are simple in machine learning anti-viral characteristics, to propose computer-aided rational drug design strategies efficient in computing docking usage, and powerful enough to achieve very high accuracy levels for this in-silico effort for the generation of the AI-Quantum designed molecule of Combination of GisitorviffirnaTM, Roccustyrna_gs1_TM, and Roccustyrna_fr1_TM ligands with Preferred IUPAC Names of (7aR)‐5‐amino‐N‐[(S)‐{2‐[(S)‐[(E)‐(amino methyl idene)amino](cyano)methyl]hydrazin‐1‐yl}(aziridin‐1‐yl)phosphoryl]‐1‐[(2E)‐2‐[(fluoromethanimidoyl)imino]acetyl]‐7‐oxo‐1H,7H,7aH‐pyrazolo[4,3‐d]pyrimidine‐3‐carboxamide; N‐{[(2‐amino‐ 6‐oxo‐6,9‐dihydro‐1H‐purin‐9‐yl)amino]({1‐[5‐ ({[cyano({1‐[(diaminomethylidene)amino]ethenyl})amino]oxy}methyl)‐3,4‐dihydroxyoxolan‐2‐yl]‐1H‐1,2,4‐triazol‐3‐yl}formamido)phosphoryl}‐6‐fluoro‐3,4‐dihydropyrazine‐2‐carboxamide;[3‐(2‐amino‐5‐sulfanylidene‐1,2,4‐triazolidin‐3‐yl)oxaziridin‐2‐yl]({3‐sulfanylidene‐1,2,4,6‐tetraazabicyclo[3.1.0]hexan‐6‐yl})phosphoroso1‐(3,4,5‐trifluorooxolan‐2‐yl)‐1H‐1,2,4‐triazole‐3‐carboxylate targeting the COVID-19-SARS-COV-2 SPIKE D614G mutation using Chern-Simons Topology Euclidean Geometric in a Lindenbaum-Tarski generated QSAR automating modeling and Artificial Intelligence-Driven Predictive Neural Networks.
General methods to quantize combined descriptors of both the probability and phase/current distributions in molecular electronic reference frame transformations, to a “superposition of coordinate transformations” have been previously introduced. Continuity equations for these densities are explored on an array of recent fundamental observations developed through gravitational amplification of primeval density fluctuations generated in the exceedingly early phase of cosmic evolution. In this paper, I show that the notion of vertical-equilibrium state of the vanishing current entanglement in chemical space and orbital superpositions are observer-dependent features in quantum reference frames including Galilean transformation, and near-horizon symmetries ranging from supergravity theories to Lorentzian cryptographic signatures to enhance the RoccuffirnaTM’s gravity to trap the SARS-COV-2 viruses in practice. The corresponding stationary radial Schrödinger equations with these potential energy functions are solved analytically, in the underlying information continuity equation that determines machine learning characteristics for both Euclidean and Lorentzian signatures to Quantum microBlackHole-Inspired Kerr- (A) dS-Myers–Perry black Gravitationals in an approximate scheme for zero total angular momentum. It is found that the wave functions for bound states can be expressed in terms of the Jacoby polynomial involving either the nonclassical or resultant entropy/information concepts the so called horizontal-equilibrium state, which represents the phase-transformed quantum state of a molecule, corresponding to the optimum, density-dependent “thermodynamic” phase in the near-horizon limit, with either SL(2, ℝ) or Poincaré iso(1, 1) symmetry which extends to the entire near-horizon geometry . This analytical expressions for purely vibrational energy levels of the electronic state, without an accompanying change of quantum observables, preserves the electron probability distribution but modifies its current by varying the moduli to a weakly-coupled description of a pharmacophoric system, where states with fixed conserved charges can be counted. The influence of the equilibrium-phase gravitational transformation, quantum phase density, and local entropy formalism production is examined on the continuity chemical relations for the anti-COVID-19 RoccuffirnaTM molecular equilibrium states.
SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally and increase infectivity by assembling more functional S protein into the virion. In this paper, I combine topology geometric methods for the generation of novel drug designs by using generalized k - nearest neighbors within a quantum computing chemical context targeting in a atomistic level the S proteins with aspartic acid (SD614) and glycine (SG614) at residue 614 protein apparatus. In this effort, I propose powerful enough computer - aided rational drug design strategies to achieve very high accuracy levels for the generation of AI - Quantum designed molecules of GisitorviffirnaTM, Roccustyrna_ gs1_TM, and Roccustyrna_fr1_TM ligands targeting the SARS - COV - 2 SPIKE D614G mutation by unifying Eigenvalue Statements into Shannon entropy quantities as composed on Tipping–Ogilvie driven Machine Learning potentials for nonzero Christoffel symbols. For this model, I find analytic black hole solutions relevant to address a vast variety of small molecule modeling problems essential to describe pharmacophore merging phenomena in the presence of chemical potentials among others at the locally AdS5 spacetime. A boundary solution in five-dimensional Chern-Simons supergravity is described in the form of a Quantum Circuit which can carry U(1) charge provided the spacetime torsion is non-vanishing. Thus, I analyze the most general configuration consistent with the local AdS5 generated D614G Binding Site isometries in Riemann-Cartan space. I also arrived at a new Zmatter derived finite ‐ dimensional state integral and a Schwarzschild (DFT) ℓneuron (ι) : = φ∘D∘r2∘S∘r102 /3[T] Ψ0⋮Ψ0Ψ0e [r] (F ∧ F ∧ F) (1o∑ ∑ ∑ ) improver for a Chern - Simons Topology and Euclidean symplectic ω = (i~)− 1/2 F (ab)J(ab) o1 ℓ T (a)J(a) oF T1 (dx/x) ∧ (dy/y) model by computing the analytically continued “holomorphic blocks” on an appropriate quantum Hilbert space H to put pharmacophoric elements back together.
SARS coronavirus 2 (SARS-CoV-2) in the viral spike (S) encoding a SARS-COV-2 SPIKE D614G mutation protein predominate over time in locales revealing the dynamic aspects of its key viral processes where it is found, implying that this change enhances viral transmission. It has also been observed that retroviruses infected ACE2-expressing cells pseudotyped with SG614 that is presently affecting a growing number of countries markedly more efficiently than those with SD614. The availability of newer powerful computational resources, molecular modeling techniques, and cheminformatics quality data have made it feasible to generate reliable algebraic calculations to design new chemical entities, merging chemicals, fragmentizing natural products, and a lot of other substances fuelling further development and growth of this AI-quantum based drug design field to balance the trade-off between the structural complexity and the quality of such biophysics predictions that cannot be obtained by any other method. In this paper, we strongly combine topology geometric methods targeting at the atomistic level the protein apparatus of the SARS-COV-2 virus that are simple in machine learning anti-viral characteristics, to propose computer-aided rational drug design strategies efficient in computing docking usage, and powerful enough to achieve very high accuracy levels for this in-silico effort for the generation of the AI-Quantum designed molecule the RoccustyrnaTM small molecule, a multi-targeting druggable scaffold 2‐({[fluoro({[(2E)‐5‐oxabicyclo [2.1.0]pentan‐2‐ylidene]cyano‐lambda6‐sulfanyl}) methyl]phosphorylidene} amino)-4,6‐dihydro‐1H‐purin‐6‐onetargeting the COVID-19-SARS-COV-2 SPIKE D614G mutation using Chern-Simons Topology Euclidean Geometric in a Lindenbaum-Tarski generated QSAR automating modeling and Artificial Intelligence-Driven Predictive Neural Networks.
It is thought that all of the rich content in the present-day Universe based on an array of recent observations developed through gravitational amplification of primeval density fluctuations generated in the very early phase of cosmic evolution. In this paper, we strongly combine machine learning characteristics to achieve very high accuracy levels for the in-silico generation of the RoccuffirnaTM small molecule, a ligand targeted the SARS-COV-2 virus main protease (M pro ) using Quantum Kerr-(A)dS and Myers–Perry black microBlackHole-Inspired Gravitational for both Euclidean and Lorentzian signatures in Practice. We provide also an extensive toolbox of methods for performing quantum schrodinger inspired docking algorithms, teleportation and other information-theoretic tasks in MathCast programming language, and compared these algorithms by means of mean percentile free energy ranking, in a new recall-based evaluation metric for the in-silico design of the Novel Series of the RoccuffirnTMQMMMCoRoNNARRFr anti-(nCoV-19) ligands. In this paper we in-silico designed new drug leads that target the COVID-19 virus main protease (M pro ). M pro, a key CoV enzyme, which plays a pivotal role in mediating viral replication and transcription, and discuss various general results including Galilean transformation to a rigid QMMM heuristic horizon topology, and near-horizon fragmentation symmetry ranging from supergravity theories to Lorentzian signatures in order to enhance the Roccuffirna’s gravity to trap the SARS-COV-2 viruses in practice.
It is thought that all of the rich content in the present-day Universe based on an array of recent observations developed through gravitational amplification of primeval density fluctuations generated in the very early phase of cosmic evolution. In this paper, we strongly combine machine learning characteristics to achieve very high accuracy levels for the in-silico generation of the RoccuffirnaTM small molecule, a ligand targeted the SARS-COV-2 virus main protease (M pro ) using Quantum Kerr-(A)dS and Myers–Perry black microBlackHole-Inspired Gravitational for both Euclidean and Lorentzian signatures in Practice. We provide also an extensive toolbox of methods for performing quantum schrodinger inspired docking algorithms, teleportation and other information-theoretic tasks in MathCast programming language, and compared these algorithms by means of mean percentile free energy ranking, in a new recall-based evaluation metric for the in-silico design of the Novel Series of the RoccuffirnTMQMMMCoRoNNARRFr anti-(nCoV-19) ligands. In this paper we in-silico designed new drug leads that target the COVID-19 virus main protease (M pro ). M pro, a key CoV enzyme, which plays a pivotal role in mediating viral replication and transcription, and discuss various general results including Galilean transformation to a rigid QMMM heuristic horizon topology, and near-horizon fragmentation symmetry ranging from supergravity theories to enhance the Roccuffirna’s gravity to trap the SARS-COV-2 viruses in practice.
SARS coronavirus 2 (SARS-CoV-2) in the viral spike (S) encoding a SARS-COV-2 SPIKE D614G mutation protein predominate over time in locales revealing the dynamic aspects of its key viral processes where it is found, implying that this change enhances viral transmission. It has also been observed that retroviruses infected ACE2-expressing cells pseudotyped with SG614 that is presently affecting a growing number of countries markedly more efficiently than those with SD614. The availability of newer powerful computational resources, molecular modeling techniques, and cheminformatics quality data have made it feasible to generate reliable algebraic calculations to design new chemical entities, merging chemicals, recoring natural products, and a lot of other substances fuelling further development and growth of this AI-quantum based drug design field to balance the trade-off between the structural complexity and the quality of such biophysics predictions that cannot be obtained by any other method. In this paper, we strongly combine topology geometric methods targeting at the atomistic level the protein apparatus of the SARS-COV-2 virus that are simple in machine learning anti-viral characteristics, to propose computer-aided rational drug design strategies efficient in computing docking usage, and powerful enough to achieve very high accuracy levels for this in-silico effort for the generation of the AI-Quantum designed molecule the RoccustyrnaTM small molecule, a multi-targeting druggable scaffold (1S,2R,3S)‐2‐({[(1S,2S,4S,5R)‐4‐ethenyl‐4‐sulfonylbicyclo[3.2.0]heptan‐2‐yl]oxy}amino)‐3‐[(2R,5R)‐5‐(2‐methyl‐6‐methylidene‐6,9‐dihydro‐3H‐purin‐9‐yl)‐3‐methylideneoxolan‐2‐yl]phosphirane‐1‐carbonitrile targeting the COVID-19-SARS-COV-2 SPIKE D614G mutation using Chern-Simons Topology Euclidean Geometric in a Lindenbaum-Tarski generated QSAR automating modeling and Artificial Intelligence-Driven Predictive Neural Networks.