Statistical analysis
Continuous data are expressed as the mean ± SD. Categorical variables were expressed as counts (percentages). Kolmogorov-Smirnov Z tests were used to evaluate the normality of the data. Parametric tests were applied when normality was satisfied, otherwise, the Mann-Whitney U tests and chi-square tests were used for nonparametric data. Time to first CAE was defined as the number of days between the start of anthracycline therapy and the date of the first CAE and was considered for survival analysis. Patients who had not experienced CAEs as of their last visit date were censored at this date. Cox proportional hazard analysis was used to determine significant clinical and echocardiographic identifiers of time to CAEs. To perform a comparison of RVEF and LVGLS, we performed a proportional hazard analysis using these two terms in a multivariate analysis. The incremental value of RVEF and LVGLS compared with RVEF in identifying subsequent CAEs was tested with chi-square tests. Receiver operating characteristic curve analysis was used to determine the relationship of LVGLS and RVEF value to the occurrence of CAEs. Survival without CAEs as a function of RVEF was analyzed using Kaplan-Meier analysis. All analyses were performed using a standard statistical software program (IBM SPSS Statistics for Windows version 23.0; IBM, Armonk, NY). P values < .05 were considered to indicate statistical significance.