Study design and participant
The present systematic review included all published research comparing the AMH concentration after SPL and MPL for treatment of ovarian benign cysts excluding diseases related to pregnancy. The meta-analysis was performed in accordance with the guidelines for Systematic Reviews and Meta-analyses (PRISMA) based on the authors’ predetermined inclusion criteria. Selection of abstracts was conducted by two authors (ET and KT) who independently searched the literature. Only articles written in English were included. Studies considered were randomized clinical trials (RCT), prospective controlled, prospective cohort, or retrospective studies. Institutional Review Board approval was not requested since the present study is a review of published studies.
An electronic database search was performed using Pubmed, Embase and Medline for the identification of studies in English published until September 2019 using a combination of the following search items: single-port laparoscopic cystectomy, ovarian reserve, laparoscopy, ovarian endometrioma, AMH. Other databases were searched and no additional studies were identified. Following the search, all articles considered pertinent on the basis of the title and abstract were retrieved and their reference lists were searched for additional potential studies. Each author independently reviewed the literature. The discrepancies during the data collection were then resolved by consensus of all authors.
Inclusion criteria included age at surgery (>18 years and <45 years), BMI between 18,5 and 24,9 (kg/k2) , cyst size 3-11 cm, unilateral or bilateral ovarian cysts presumed as benign (endometriomas, dermoid cysts, simple cysts, serous cystadenomas, mucinous cystadenomas) on ultrasonography, regular menstrual cycle (21-35 days). Exclusion criteria were: presence of endocrine disorders, use of any medications such as oral contraceptive pills or other hormonal agents within three months before study enrollment, previous history of ovarian cyst surgery, radiotherapy or chemotherapy and pregnant women. All patients underwent the procedure under general anesthesia with endotracheal intubation and were placed in the Trendelenburg position (Table 1)