Data analysis
One radiologist performed sonoelastography measurements for all
subjects. Two radiologists (S.S.E and A.K with 2 years of experience in
elastography and 30 years of conventional US experience, respectively)
determined the final interpretations through consensus. The radiologists
were blind to the clinical information of the patients with MS (with or
without optic neuritis).
Quantitatively analysis of optic nerve, optic disc, and perineural area
stiffness was expressed as kPa with a color scale of 0-150 kPa and a
region of interest at an interval of 2 to 3 mm. Three measurements for
the quantitative value of each optic nerve, optic disc, and perineural
area were acquired and the average values were used for the statistical
analysis. (Fig1 and 2)