References:
1. Weatherall DJ: Thalassemia in the Next Millennium: Keynote Address a. Annals of the New York Academy of Sciences 1998:850:1-9.
2. SL Thein: Genetic modifiers of beta-thalassemia. Haematologica 2005:90:649-660.
3. Dubey AP, Parakh A, Dublish S: Current trends in the management of beta thalassemia. The Indian Journal of Pediatrics 2008:75:739.
4. Modell B, Khan M, Darlison M, et al: Improved survival of thalassaemia major in the UK and relation to T2* cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance 2008:10:42.
5. Rooyakkers TM, Stroes ESG, Kooistra MP, et al: Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vivo. European Journal of Clinical Investigation 2002:32:9-16.
6. Murphy CJ, Oudit GY: Iron-overload cardiomyopathy: pathophysiology, diagnosis, and treatment. Journal of Cardiac Failure 2010:16:888-900.
7. Lang RM, Badano LP, Mor-Avi V, et al: Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. European Heart Journal-Cardiovascular Imaging 2015:16:233-271.
8. Kapetanakis S, Kearney MT, Siva A, et al: Real-time three- dimensional echocardiography: a novel technique to quantify global left ventricular mechanical dyssynchrony. Circulation 2005:112:992-1000.
9. Kasikcioglu HA, Karasulu L, Durgun E, et al: Aortic elastic properties and left ventricular diastolic dysfunction in patients with obstructive sleep apnea. Heart and Vessels 2005:20:239-244.
10. Corretti MC, Anderson TJ, Benjamin EJ, et al: Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. Journal of the American College of Cardiology 2002:39:257-265.
11. Bots ML, Westerink J, Rabelink TJ, et al: Assessment of flow-mediated vasodilatation (FMD) of the brachial artery: effects of technical aspects of the FMD measurement on the FMD response. European Heart Journal 2005:26:363-368.
12. Vogel RA: Measurement of endothelial function by brachial artery flow-mediated
vasodilation. The American Journal of Cardiology 2001:88:31-34.
13. Pennell DJ: T2* magnetic resonance and myocardial iron in thalassemia. Annals of the New York Academy of Sciences 2005:1054:373-378.
14. Moussavi F, Ghasabeh MA, Roodpeyma S, et al: Optimal method for early detection of cardiac disorders in thalassemia major patients: magnetic resonance imaging or echocardiography? Blood Research 2014:49:182-186.
15. Pennell DJ, Udelson JE, Arai AE, et al: American heart association committee on heart failure and transplantation of the council on clinical cardiology and council on cardiovascular radiology and imaging. Cardiovascular function and treatment in β-thalassemia major: a consensus statement from the american heart association. Circulation 2013:128:281-308.
16. Abtahi F, Abdi A, Jamshidi S, et al: Global longitudinal strain as an Indicator of cardiac Iron overload in thalassemia patients. Cardiovascular Ultrasound 2019:17:24.
17. Eghbali A, Taherahmadi H, Shahbazi M, et al: Association between serum ferritin level, cardiac and hepatic T2-star MRI in patients with major β-thalassemia. Iranian journal of Pediatric Hematology and Oncology 2014:4:17.
18. Wahidiyat PA, Liauw F, Sekarsari D, et al: Evaluation of cardiac and hepatic iron overload in thalassemia major patients with T2* magnetic resonance imaging. Hematology 2017:22:501-507.
19. Kim E, Giri SN, Pessah IN: Iron (II) is a modulator of ryanodine-sensitive calcium channels of cardiac muscle sarcoplasmic reticulum. Toxicology and Applied Pharmacology 1995:130:57-66.
20. Mavrogeni SI, Markussis V, Kaklamanis L, et al: A comparison of magnetic resonance imaging and cardiac biopsy in the evaluation of heart iron overload in patients with β‐thalassemia major. European Journal of Haematology 2005:75:241-247.
21. Penicka M, Bartunek J, De Bruyne B, et al: Improvement of left ventricular function after cardiac resynchronization therapy is predicted by tissue Doppler imaging echocardiography. Circulation 2004:109:978-983.
22. Leclercq C, Faris O, Tunin R, et al: Systolic improvement and mechanical resynchronization does not require electrical synchrony in the dilated failing heart with left bundle-branch block. Circulation 2002:106:1760-1763.
23. Liodakis E, Al Sharef O, Dawson D, et al: The use of real-time three- dimensional echocardiography for assessing mechanical synchronicity. Heart 2009:95:1865-1871.
24. Bae BS, Kim KJ, Park JG, et al. Improvement in left ventricular systolic dyssynchrony in hypertensive patients after treatment of hypertension. Korean Circulation Journal 2011:41:16–22.
25. Borgna-Pignatti C, Cappellini MD, De Stefano P, et al: Survival and complications in thalassemia. Annals of the New York Academy of Sciences 2005:1054:40-47.
26. Cappellini MD: Prevalence of thromboembolic events among 8,860 patients with thalassaemia
major and intermedia in the Mediterranean area and Iran. Thromb Haemost 2006:96:488-91.
27. Minneci PC, Deans KJ, Zhi H, et al: Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. The Journal of Clinical Investigation 2005:115:3409-3417.
28. Morris CR, Kato GJ, Poljakovic M, et al: Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. JAMA: Journal of the American Medical Association 2005:294:81–90.
29. Hahalis G, Kremastinos DT, Terzis G, et al: Global vasomotor dysfunction and accelerated vascular aging in β-thalassemia major. Atherosclerosis 2008:198:448-457.
30. Heitzer T, Schlinzig T, Krohn K, et al: Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001:104:2673-2678.
31. Mancini GJ, Dahlöf B, Diez J: Surrogate markers for cardiovascular disease: structural markers. Circulation 2004:109:IV-22–IV-30
32. Stakos DA, Margaritis D, Tziakas DN, et al: Cardiovascular involvement in patients with β-thalassemia major without cardiac iron overload. International Journal of Cardiology 2009:134:207-211.
33. Gupta A, Kapoor A, Phadke S, et al: Use of strain, strain rate, tissue velocity imaging, and endothelial function for early detection of cardiovascular involvement in patients with beta-thalassemia. Annals of Pediatric Cardiology 2017:10:158.