Study Demographics
In the present study, 20 subjects with or without renal impairment were enrolled. The participants, involving 14 males and 6 females, were characterized by a wide range of ages (26–70 years) and body weights (48.7–84.0 kg) (Table 1). The mean eGFR was 16.8 ± 6.0 ml/min/1.73 m2 in the renal impairment group (n = 10) and 107.3 ± 11.1 ml/min/1.73 m2 in the healthy control group (n = 10). Ten patients with severe renal impairment and two healthy subjects reported concomitant medications during follow-up period. The three most frequently used concomitant medications were amlodipine, sodium bicarbonate, and compound α-ketoacid tablets.