Figure 2. Visual predictive check (VPC) of nemonoxacin for the
final model. Observed concentrations were plotted using the blue circle
(○), and censored concentrations were plotted using star (*). The shaded
area represents the 90% prediction interval and the predicted median of
the 10th, 50th and
90th percentiles of simulated data (n = 1000). The
lines represent the 10th, 50th and
90th percentiles of observed concentrations.
Figure 3. Comparison of simulated daily AUC (n = 1000) of
nemonoxacin between normal renal function control and renal impairment
groups treated with different multiple-dose regimens. The shaded area
represents the 1/2 ~ 2 times of the AUC/AUC ratio
interval. The data in the right panel represent geometric mean and 90%
CI.