Control n=240 Localizeda n=76 Advanceda n=104
Localizeda vs. control
Localizeda vs. control
Advanceda vs. control
Advanceda vs. control
Advanceda vs. control
Advancedavs. localizeda
Advancedavs. localizeda
n (%) n (%) n (%) aORb 95% CI aORb 95% CI 95% CI aORb 95% CI
Melatoninc Melatoninc Melatoninc Melatoninc Melatoninc Melatoninc Melatoninc Melatoninc Melatoninc Melatoninc Melatoninc Melatoninc
Low 108 (45.0) 40 (52.9) 69 (66.7) 1.0 (Ref) 1.0 1.0 (Ref) 1.0 (Ref)
High 132 (55.0) 36 (47.1) 35 (33.3) 0.72 0.38–1.36 0.49 0.49 0.26–0.89 0.61 0.27–1.28
Cortisolc Cortisolc Cortisolc Cortisolc Cortisolc Cortisolc Cortisolc Cortisolc Cortisolc Cortisolc Cortisolc Cortisolc
Low 129 (53.7) 36 (47.1) 39 (37.7) 1.0 (Ref) 1.0 1.0 (Ref) 1.0 (Ref)
High 111 (46.3) 40 (52.9) 65 (62.3) 1.28 0.68–2.41 1.96 1.96 1.07–3.57 1.87 0.87–4.01
*MT/Cc *MT/Cc *MT/Cc *MT/Cc *MT/Cc *MT/Cc *MT/Cc *MT/Cc *MT/Cc *MT/Cc *MT/Cc *MT/Cc
Low 105 (43.8) 40 (52.9) 72 (69.6) 1.0 (Ref) 1.0 1.0 (Ref) 1.0 (Ref)
High 135 (56.2) 36 (47.1) 32 (30.4) 0.63 0.33–1.20 0.33 0.33 0.17–0.62 0.44 0.20–0.99
Preoperative PSA Preoperative PSA Preoperative PSA Preoperative PSA Preoperative PSA Preoperative PSA Preoperative PSA Preoperative PSA Preoperative PSA Preoperative PSA Preoperative PSA Preoperative PSA
< 10 ng/mL < 10 ng/mL 120 (52.4) 28 (36.8) 12 (11.5) 1.0 (Ref) 1.0 1.0 (Ref) 1.0 (Ref)
≥ 10 ng/mL ≥ 10 ng/mL 109 (47.6) 48 (63.2) 92 (88.5) 2.13 1.10–4.15 8.17 8.17 3.77–17.72 3.88 1.49–10.09
MT/Cc PSA**
High < 10 63 (26.3) 12 (16.0) 3 (2.9) 1.0 (Ref) 1.0 1.0 (Ref) 1.0 (Ref)
Low < 10 57 (23.7) 15 (20.0) 9 (8.7) 1.44 0.52–3.97 3.71 3.71 0.71–19.44 2.57 0.40–16.64
High ≥ 10 61 (25.4) 23 (30.0) 29 (27.8) 2.16 0.85–5.46 9.36 9.36 2.04–42.91 4.34 0.79–23.93
Low ≥ 10 48 (24.6) 26 (34.0) 63 (60.6) 3.41 1.34–8.69 32.06 32.06 7.17–143.29 9.41 1.77–50.07
P for multiplicative interaction
0.888
0.888
0.930
0.930
0.930
0.871
0.871