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Introduction
Remodeling is resulting in molecular, cellular and interstitial changes
and manifested clinically as changes in size, shape and function of the
heart resulting from cardiac load or injury. Cardiac remodeling is
influenced by hemodynamic load, neurohormonal activation , and other
factors still under investigation. Medical and device therapies that
reduce heart failure morbidity and mortality also lead to decreased left
ventricular volume and mass and a more normal elliptical shape of the
ventricle. These are due to changes in myocyte size, structure, and
organization that have been referred to collectively as reverse
remodeling. Moreover, there are subsets of patients whose hearts have
undergone reverse remodeling either spontaneously or after medical or
device therapies and whose clinical course is associated with freedom
from future heart failure events. However right side changes do occur
along with reverse remodeling but still under investigation.