RESULT
The overall study consisted of 1003 patients; a mean age of 62.9 ± 10.8
years, of whom 755 (75.3%) were male and 248 (24.7%) were female.
Hypertension was the most identified risk factor in 452 patients
(45.1%), and 279 of all patients (27.8%) had diabetes mellitus.
In-hospital mortality occurred in 69 patients (6.87%).
Patients were divided into two groups according to in-hospital
mortality. 934 patients without in-hospital mortality were defined as
Group I, and 69 patients who died in the hospital were defined as Group
II. Compared to Group I, Group II patients were significantly older
(62.5 ± 10.8 vs. 67.45 ± 10.1, p=0.001). Comparisons of the groups with
respect to the laboratory data revealed that Group II had significantly
lower hemoglobin levels, albumin levels, (p=0.001). Preoperative serum
creatinine levels were significant differences between Group I and Group
II (1.0 ± 0.02 vs. 1.3 ± 0.1; p=0.01, respectively). Compared to Group
I, PNI level was significantly lower in the Group II (48.34 ± 6.71 vs.
44.76 ± 7.63, respectively, p=0.001). The mean BMI was similar between
the groups (26.70 ± 2.87 vs. 26.54 ± 2.60 p=0.66). Preoperative LVEF was
statistically lower in the Group II rather than the Group I (51.6 ± 0.3
vs. 44.5 ± 1.2; P=0.001). Since the infection was broadly categorized in
our study, we compared hospital-acquired infection between groups. There
was a significantly different a higher tendency of hospital-acquired
infection in the Group II (151; 16.2% vs. 44; 63.8%; p=0.001).
Postoperative stroke significantly higher in the Group II (35; 3.7% vs.
62; 89.9%; p=0.001). Multivariate analysis revealed that X-clamp time
(p<0.005), CPB time (p=0.001), IABP usage (p=0.001), and ICU
stay (p=0.001) significantly higher in the Group II.
The demographic, clinical, echocardiographic, biochemical data of the
two groups were shown in Tables 2 and 3.
In the receiver-operating characteristic analysis, PNI lower than 42.6
predicted in-hospital mortality with 82% sensitivity and 42.6 %
specificity [area under the curve 0.64, 95% confidence interval 0.572
- 0.714; p=0.001] (Figure1). Multivariate analysis revealed that male
sex (95% confidence interval 1.29 - 11.91, p=0.016), age (95%
confidence interval 1.11 - 10.15, p=0.032), and the PNI (95% confidence
interval 0.18 - 0.90, p=0.026) were independently associated with
postoperative survival.