Study population
This study included adult patients with CVID meeting the European Society for Immunodeficiency (ESID)/International Consensus Document (ICON) diagnostic criteria , and vaccination was indicated by the attending immunologist and performed by specialized vaccination centers. Patients with pre-vaccination reverse transcription polymerase chain reaction (RT-PCR)-confirmed SASRS-CoV-2 infection or severe non-infectious complications were excluded. Their results were compared with those of corresponding sex- and age-matched healthy controls (HCs).