Conclusion
This work highlights the importance of many factors when evaluating the outcomes of TMD treatment. Consistent assessment reporting tools would allow appropriate comparison of results, facilitating the development of a consensus on the therapeutic benefit of botulinum toxin. Since TMD pain is not always eliminated with conservative treatment methods, such as physical therapy or occlusal splint, other treatment options must be devised. The diagnostic tools and treatment response evaluation methods described herein serves as a novel model to perform a scientifically sound examination when investigating the efficacy of botulinum toxin and other treatment modalities in TMD patients.