Toxicity
Regarding hematological toxicities all patients in the augmented therapy
group were admitted with febrile neutropenia post each block of
intensive therapy, seven of 48 patients needed intensive care and
another four patients had invasive fungal infections, all are alive.
Notably, all had grade 3 anemia, and grade 3-4 thrombocytopenia; the
toxic effects of augmented therapy were considerable but manageable with
no treatment related death. Non- Hematological toxicities between two
groups were comparable.