Toxicity
Regarding hematological toxicities all patients in the augmented therapy group were admitted with febrile neutropenia post each block of intensive therapy, seven of 48 patients needed intensive care and another four patients had invasive fungal infections, all are alive. Notably, all had grade 3 anemia, and grade 3-4 thrombocytopenia; the toxic effects of augmented therapy were considerable but manageable with no treatment related death. Non- Hematological toxicities between two groups were comparable.