METHODS
In this retrospective study, 233 KTRs were included in the study in our
out-patient clinic for routine control within 12 months. KTRs according
to uric acid level; uric acid> 7 mg / dL for men
and> 6mg / dl for women were considered to be high SUA (n:
113). Allopurinol treatment was started at post-transplant
>3.Month-<12. month. The remaining 120 patients
had normal SUA levels. Fiftyseven KTRs with high SUA levels received
allopurinol treatment and 56 patients did not. There were 118 patients
who were followed for more than 5 years and they were evaluated
separately. Of these, 56 had high SUA levels and 62 were normal. Of the
56 patients with high SUA level, 26 received allopurinol treatment and
30 did not (Table 1). Allopurinol group received 150 mg allopurinol
treatment every other day. Patients also received triple
immunosuppressive therapy (CNI + MMF or mTOR inhibitor and prednisolone)
as standard therapy. In addition, they continued to antihypertensive
drugs as needed.
Exclusion criterias: Patients with acute renal insufficiency, clinically
overt heart failure, hepatic insufficiency, uncontrolled blood pressure
(> 140 / 90mm / Hg) and diuretic therapy.
Age, sex, transplant date and laboratory results including serum uric
acid, BUN, creatinine, sodium, potassium, chlorine, calcium, total
protein, albumin, blood counts and drug levels were provided
retrospectively from medical records. Visits were shown as 1. Baseline,
2. 6. Month, 3. 1. Year, 4: 2. year, 5. 5. year. Glomerular filtration
rate (GFR) was measured using CKD-epi. Permanent reduction of GFR to 10
ml/min was considered as graft loss.
For statistical analysis SPSS 20.0 windows package program was used and
p value <0.05 was considered significant. Frequency analysis,
chi-square test, t-test and correlation analysis were used. To evaluate
the change in the measurements obtained in the time interval, The
Repeated Measurements Analysis was applied.
Ethical considerations
Written approval from the Ethics Board of Cukurova University Faculty of
Medicine was obtained for the study.