3.4.5 Renal function
There were 19 studies comparing serum creatinine level(Fig.7) in the CRRT combination control group. Due to heterogeneity (I2>90%), random effect model analysis was used, and the difference between the two groups was statistically significant(WMD=-95.59, 95%CI-126.71 to -64.46, P<0.00001). Based on the subgroup analysis of whether the Scr was greater than 95 clinically, we concluded that the CRRT group presented a more significant degree of decreased creatinine value regardless of whether the patients’ creatinine value was normal after treatment. However, there was great heterogeneity. After analyzing factors such as age, gender and treatment time, I2 was more than 70%. So the inter-group heterogeneity of the two indicators was considered to be clinically possible.