3.4.7 Other outcome measures
Nineteen studies analyzed the clearance effect of serum amylase in the
CRRT group and the control group, and the heterogeneity was
large(I2>95%). There were respectively 9
and 15 studies compared the impact of CRRT group and control group on
IL-6 and TNF-α clearance effect. In the same way, both outcomes have the
large heterogeneity (I2>95%). We
attempted to conduct a subgroup analysis of each study by age,
population and the treatment time, but the results showed that there was
great heterogeneity between groups, all of which exceeded 90%.
Therefore, we considered that the main source of heterogeneity may was
clinical heterogeneity. For this reason, we conducted a systematic
evaluation of the above outcome indicators, the results showed that the
application of CRRT was superior to the conventional treatment in
reducing the level of inflammatory factors in patients. Among them, in
terms of IL-6 clearance, all the studies after CRRT were controlled
below 140, while 5 studies with conventional treatment were above 200.
In terms of TNF-α clearance effect, 6 studies were reduced to less than
50 and 12 to less than 100 after CRRT treatment, while only 2 were
reduced to less than 50 and 6 were reduced to less than 100 in the
conventional group. The difference between the two groups was
statistically significant(P<0.00001).
Similarly for serum amylase, 11 of the patients in the CRRT group had
serum amylase levels below 200 after treatment, compared with only 1 in
the conventional treatment group. In terms of safety, ALT levels were
analyzed 11 studies, patients in the CRRT treatment group had AST over
40 in 6 studies and over 40 in 9 studies in the conventional group. The
difference between the two groups was statistically
significant(P<0.00001).