Introduction:
Etoposide is an antineoplastic agent used in more than a dozen pediatric chemotherapeutic regimens. Case reports have described infusion related adverse drug reactions (ADRs) with etoposide.1-4 The package insert reports anaphylactic-like reactions including chills, fever, tachycardia, bronchospasm, dyspnea, and hypotension occurring in 0.7-2% of patients receiving etoposide.5 Primary literature estimates infusion reactions occur in 1.3-27.1% of patients receiving etoposide.6,7 We present a ten-year experience of etoposide, and describe infusion related reactions at two freestanding pediatric hospitals.