Introduction:
Etoposide is an antineoplastic agent used in more than a dozen pediatric
chemotherapeutic regimens. Case reports have described infusion related
adverse drug reactions (ADRs) with etoposide.1-4 The
package insert reports anaphylactic-like reactions including chills,
fever, tachycardia, bronchospasm, dyspnea, and hypotension occurring in
0.7-2% of patients receiving etoposide.5 Primary
literature estimates infusion reactions occur in 1.3-27.1% of patients
receiving etoposide.6,7 We present a ten-year
experience of etoposide, and describe infusion related reactions at two
freestanding pediatric hospitals.