Conclusion:
The present study can be accepted as a preliminary report on metabolomic
alterations in BD patients with or without vascular involvement. As the
etiopathogenesis of this chronic inflammatory disease is still not
clearly known, our study can suggest some metabolomic indicators of
disease prognosis. Especially for vascular involvement, finding a
non-invasive molecule is of critical importance for both diagnosis and
treatment of disease. As BD is accepteda as a vasculitis and endothelial
dysfunction seems to be the pathognomonic signature of the disease, the
early detection of candidate oxidative stress markers causing
endothelial damage may bring early diagnosis and better clinical
management.