Results:
In this study, we focused on dynamic plasma metabolome structure to
understand the physiological fundamentals of BD and VBD using
GC-MS-based metabolomics analysis. Untargeted metabolomics analysis
covered a comparison of metabolome between healthy and BD and VBD
groups. In metabolomics analysis, we totally identified 168 metabolites.
Metabolomics results of BD and healthy control groups compared to
understand physiological changes in BD (Figure 1) . 11 metabolites
decreased and 3 metabolites increased in BD group (Figure 1C) and these
metabolites have a molecular function in various pathways (Figure 1D).
VBD is a rare type of BC and there is limited information about this
condition. First, we compared the metabolome of VBD and healthy control
groups and altered metabolites and their pathways were given in Figure
2.
VBD and BD comparison is another important goal in understanding the
mechanism of vascular involvement in BD. Results showed that various
metabolites involved in amino acid metabolism were significantly
downregulated in VBD groups. Seven metabolites decreased in the VBD
group and only hydroxyphenylacetic acid increased in the VBD group.
These metabolites are involved in amino acid metabolism, sulfur
metabolism and also methionine metabolism