Results:
In this study, we focused on dynamic plasma metabolome structure to understand the physiological fundamentals of BD and VBD using GC-MS-based metabolomics analysis. Untargeted metabolomics analysis covered a comparison of metabolome between healthy and BD and VBD groups. In metabolomics analysis, we totally identified 168 metabolites.
Metabolomics results of BD and healthy control groups compared to understand physiological changes in BD (Figure 1) . 11 metabolites decreased and 3 metabolites increased in BD group (Figure 1C) and these metabolites have a molecular function in various pathways (Figure 1D).
VBD is a rare type of BC and there is limited information about this condition. First, we compared the metabolome of VBD and healthy control groups and altered metabolites and their pathways were given in Figure 2.
VBD and BD comparison is another important goal in understanding the mechanism of vascular involvement in BD. Results showed that various metabolites involved in amino acid metabolism were significantly downregulated in VBD groups. Seven metabolites decreased in the VBD group and only hydroxyphenylacetic acid increased in the VBD group. These metabolites are involved in amino acid metabolism, sulfur metabolism and also methionine metabolism