EFS Events
Of the 112 eligible patients, 78 received protocol-prescribed cranial radiation (1200 cGy in 64 and 1800 cGy in 14 patients following the amendment). Thirty-two patients did not receive protocol prescribed cranial radiation as they came off protocol prior to that timepoint for the following reasons: physician or patient discretion (19), relapse (10), and death (3). An additional 2 patients completed the protocol-prescribed chemotherapy but did not receive radiation.
EFS events are summarized in Table 1 and Supplementary Table 2 . Of the 6 remission deaths, 1 occurred post-radiation. Of the 39 patents who experienced a subsequent relapse, 19 received chemotherapy without protocol-prescribed radiation and 20 received radiation and chemotherapy as per protocol - 2 during the radiation reporting period and 18 while in Maintenance. Patients who had an event prior to scheduled radiation at 12 months are included in the group of 19 patients. Of the 20 relapsed patients who received protocol prescribed radiation, 15 received 1200 cGy and 5 received 1800 cGy (post amendment).