Abstract
Male infertility may be the result of some identifiable conditions
(varicocele, undescended testicle, hypogonadism, and genetic
abnormalities), but there is no identified cause in 30-40% of infertile
men. Studies show that the use of antioxidants has a beneficial effect
on fertility, especially on sperm quality, and therefore recommended as
a potentially effective treatment for male infertility. However, it is
argued that this treatment is not based on sufficient evidence and has
no effect on the rate of healthy pregnancy.
Aim: In this study, two different antioxidant combinations with
different doses and contents were evaluated in terms of their effect on
sperm parameters.
Materials and Methods: A total of 122 patients diagnosed with
idiopathic infertility were enrolled in our multicenter study. The
patients were divided into two different groups: The first group used
Proxeed Plus sachets 2x1 (L-carnitine 1 g, acetyl-L-carnitine 0.5 g,
fructose 1 g, citric acid 0.50 mg, selenium 50 mcg, coenzyme Q10 20 mg,
vitamin C 90 mg, zinc 10 mg, folic acid 200 mcg, and vitamin B12 1.5
mcg) and the second group used Carniact Duo tablets 2x1 ((L-carnitine
500 mg, selenium 50 mcg, coenzyme Q10 20 mg, vitamin C 60 mg, zinc 15
mg, folic acid 400 mcg, vitamin E and ginseng 15 mcg) for six months.
The total semen volume, total sperm count and concentration, motile
sperm count, and morphological findings of the patients were compared at
the end of the six months. The mean age of the patients participating in
the study was 30.8 ± 6.05 years.
Results: No significant difference was found between the two
groups in terms of baseline sperm count. There was a significant
difference between the baseline and sixth-month values of the patients
using both combinations. However, no significant statistical difference
was found between the groups according to the sixth-month data.
Conclusion: The combinations of both antioxidants had a
positive effect on sperm parameters, and the use of different doses and
contents had a similar effect.
Keywords: Antioxidants, Infertility, Vitamins, Spermiogram,