Conclusions
Although it is not possible to make a definitive recommendation on
antioxidant therapy for the treatment of idiopathic male infertility,
increasing evidence from randomized trials and systematic reviews
suggests that oral antioxidant supplementation can improve semen
parameters and the probability of pregnancy. However, these studies are
not sufficient and there is a wide variation in the treatment regimens
used. Therefore, to select the optimal population that can benefit from
oral antioxidant therapy and to evaluate the effect of standardized
specific antioxidant doses on both spontaneous and assisted pregnancy
rates, there is a need for larger randomized controlled studies to
investigate different molecules and their combinations.