Conclusions
Although it is not possible to make a definitive recommendation on antioxidant therapy for the treatment of idiopathic male infertility, increasing evidence from randomized trials and systematic reviews suggests that oral antioxidant supplementation can improve semen parameters and the probability of pregnancy. However, these studies are not sufficient and there is a wide variation in the treatment regimens used. Therefore, to select the optimal population that can benefit from oral antioxidant therapy and to evaluate the effect of standardized specific antioxidant doses on both spontaneous and assisted pregnancy rates, there is a need for larger randomized controlled studies to investigate different molecules and their combinations.