Conclusion
Based on the analysis of the studies included in this systematic review
and meta-analysis, Varenicline may have a positive effect on smoking
cessation in people with alcohol dependence in the short-term. However,
Naltrexone, Topiramate, and Bupropion appear to have no clear effect on
increasing smoking abstinence among drinkers. In particular, the small
number of studies and low certainty of evidence have increased the
uncertainty of the results. Therefore, in order to produce long-term and
extensive evidence, more studies are needed to support these
conclusions.